Title:
【発明の名称】GM3を合成する方法
Document Type and Number:
Japanese Patent JP2002503668
Kind Code:
A
Abstract:
The invention describes an improved method for making monosialoganglioside GM3 and its intermediates. Following reaction of a neuraminic acid donor and a lactose acceptor in the presence of an acid catalyst, the alpha and beta isomers of GM3 are formed. The alpha isomer is converted to a lactone, via action of a ring forming basic catalyst, which is then separable from the beta isomer. The lactone is then treated with a basic catalyst in the presence of an alcohol, to form GM3 or a GM3 intermediate.
Inventors:
Schmidt, Richard
Castro-Palomino, Yurio, Tse
Ritter, Gerd
Old, Lloyd, Jay
Castro-Palomino, Yurio, Tse
Ritter, Gerd
Old, Lloyd, Jay
Application Number:
JP2000531456A
Publication Date:
February 05, 2002
Filing Date:
February 17, 1999
Export Citation:
Assignee:
Ludwig Institute for Cancer Research
International Classes:
A61P35/00; A61P37/02; C07B61/00; C07H15/10; C07H1/00; C07H3/06; C07H13/04; C07H15/18; (IPC1-7): C07H15/18
Attorney, Agent or Firm:
Shuichiro Kitamura