Title:
【発明の名称】6,9-ジ置換2-[トランス-(4-アミノシクロヘキシル)アミノ]プリン
Document Type and Number:
Japanese Patent JP2002504553
Kind Code:
A
Abstract:
The present invention provides novel compounds of formula (I) wherein R is selected from the group consisting of R2, R2NH-, or H2N-R3- wherein R2 is selected from the group consisting of C1-C8 alkyl and formula (II), wherein Z is selected from the group consisting of phenyl, heterocycle and cycloalkyl, each R4 is independently hydrogen or C1-C4 alkyl, and n is an integer 1-8; wherein each C1-C8 alkyl and Z is optionally substituted with 1 to 3 substituents, which may be the same or different, selected from the group consisting of Hal, OH, and C1-C4 alkyl; R3 is C1-C8 alkylene; and R1 is selected from the group consisting of cyclopentyl and isopropyl, and the pharmaceutically acceptable salts, optical isomers, and hydrates thereof. In addition, the present invention provides a method of inhibiting cell cycle progression. More specifically, the present invention provides a method of inhibiting cyclin dependent kinases, particularly cdk-2. The present invention also provides a method of preventing apoptosis in neuronal cells and a method of inhibiting the development of neoplasms. In addition, the present invention provides a composition comprising an assayable amount of a compound of formula (I) in admixture or otherwise in association with an inert carrier. The present invention also provides a pharmaceutical composition comprising an effective inhibitory amount of a compound of formula (I) in admixture or otherwise in association with one or more pharmaceutically acceptable carriers or excipients.
Inventors:
Jennifer A. Dumont
Alan Jay Bitonety
David Earl Bohr Sharding
Norton Pee Pete
H. Rundle Manson
Patrick Double You Kay Shum
Alan Jay Bitonety
David Earl Bohr Sharding
Norton Pee Pete
H. Rundle Manson
Patrick Double You Kay Shum
Application Number:
JP2000533431A
Publication Date:
February 12, 2002
Filing Date:
February 18, 1999
Export Citation:
Assignee:
Aventis Pharmaceuticals Incorporated
International Classes:
A61K31/52; A61P25/00; A61P35/00; A61P35/02; C07D473/16; (IPC1-7): C07D473/16; A61K31/52; A61P25/00; A61P35/00; A61P35/02
Attorney, Agent or Firm:
Chika Takagi (2 outside)