Title:
【発明の名称】カスパーゼのインヒビター
Document Type and Number:
Japanese Patent JP2002506878
Kind Code:
A
Abstract:
The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1² converting enzyme ("ICE") inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1- ("IL-1"), apoptosis-, interferon-³ inducing factor-(IGIF), or interferon-³-("IFN-³") mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN-³ production and methods for treating interieukin-1, apoptosis-, and interferon-³ mediated diseases using the compounds and compositions of this invention. This invention also relates to methods of preparing the compounds of this invention.
Inventors:
Wannamaker, Marion W.
Bemis, Guy W.
Charifson, Paul S.
Raffer, David Jay.
Murican, Michael Dee.
Murco, Mark A.
Wilson, Keith Pee.
Janetka, James W.
Davis, Robert Jay.
Grilot, Anne-Laura
Shi, Zan
Forster, Cornelia Jay.
Bemis, Guy W.
Charifson, Paul S.
Raffer, David Jay.
Murican, Michael Dee.
Murco, Mark A.
Wilson, Keith Pee.
Janetka, James W.
Davis, Robert Jay.
Grilot, Anne-Laura
Shi, Zan
Forster, Cornelia Jay.
Application Number:
JP2000536738A
Publication Date:
March 05, 2002
Filing Date:
March 19, 1999
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K31/47; A61K38/00; A61K38/03; A61K38/04; A61P5/48; A61P7/00; A61P9/00; A61P17/00; A61P19/00; A61P19/08; C07D207/273; A61P19/10; A61P25/00; A61P29/00; A61P31/04; A61P35/00; A61P37/00; A61P37/06; A61P43/00; C07D401/12; C07K5/02; C07K5/023; (IPC1-7): C07K5/023; A61K38/00; A61P19/08; A61P19/10; A61P29/00; A61P31/04; A61P35/00; A61P37/06; A61P43/00; C07D207/273
Domestic Patent References:
| JP2001501923A | 2001-02-13 | |||
| JPH09165360A | 1997-06-24 | |||
| JPH06340691A | 1994-12-13 | |||
| JPH05255218A | 1993-10-05 | |||
| JPH0789951A | 1995-04-04 | |||
| JP2006206600A | 2006-08-10 |
Foreign References:
| GB2292149A | 1996-02-14 | |||
| WO1995035308A1 | 1995-12-28 | |||
| WO1997022619A2 | 1997-06-26 |
Attorney, Agent or Firm:
Shusaku Yamamoto