Title:
【発明の名称】低酸素誘導ヒト遺伝子、タンパク質およびそれらの使用
Document Type and Number:
Japanese Patent JP2002507405
Kind Code:
A
Abstract:
The polynucleotide and polypeptide sequences of two novel hypoxia-inducible human genes, HIG1 and HIG2, are described. In addition, a number of known genes have now been established as being hypoxia-inducible. These genes include annexin V, lipocortin 2, hnRNP A1, Ku autoantigen, phosphoribosylpyrophosphate synthetase, acetoacetylCoA thiolase, ribosomal L7, fibroblast growth factor-3, EPH receptor ligand, plasminogen activator inhibitor-1, macrophage migration inhibitory factor, fibronectin receptor, lysyl hydroxylase-2, endothelin-2, B-cell translocation gene-1, reducing agent and tunicamycin-responsive protein, CDC-like kinase-1, quiescin, growth arrest DNA damage-inducible protein 45, DEC1, low density lipoprotein receptor related protein, hamster hairy gene homologue, adipophilin, cyclooxygenase-1, fructose bisphosphatase, creatine transporter, fatty acid binding protein, lactate dehydrogenase, Bcl-2-interacting killer, Nip3L/Nix, and Pim-1. Polynucleotide and polypeptide arrays comprising the hypoxia-inducible gene sequences, proteins, or antibodies which specifically bind the proteins are disclosed. Methods for using the hypoxia-inducible gene sequences and proteins, and arrays thereof, to diagnose and treat hypoxia-related conditions such as cancer and ischemia are also provided.
Inventors:
Nicholas C. Denko
Amato Jay Jachia
Christopher Jay Green
Keith Earl Raidroute
Cornelia Schindler
Albert Ching-Way Coon
Amato Jay Jachia
Christopher Jay Green
Keith Earl Raidroute
Cornelia Schindler
Albert Ching-Way Coon
Application Number:
JP2000537898A
Publication Date:
March 12, 2002
Filing Date:
March 29, 1999
Export Citation:
Assignee:
The Board of Trustees of the Leland Stanford Junior University
SRI International
SRI International
International Classes:
G01N33/50; A61K31/711; A61K48/00; A61P35/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12Q1/68; C12Q1/6883; (IPC1-7): C12N15/09; A61K31/711; A61K48/00; A61P35/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; G01N33/50
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)