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Title:
【発明の名称】キノリンピペラジンおよびキノリンピペリジン誘導体、それらの製造方法、ならびに複合的5-HT1A、5-HT1Bおよび5-HT1D受容体アンタゴニストとしてのそれらの用途
Document Type and Number:
Japanese Patent JP2002508366
Kind Code:
A
Abstract:
The invention relates to compounds of formula (I) or a salt thereof in which R is selected from a group of formula (i), (ii) or (iii); L is a group of formula -Y-C(=O)-DG- or -C(=O)-DG- or -DG-C(=O)- in which Y is -NH-, NR<5> where R<5> is C1-6alkyl, or Y is -CH2- or -O-; D is nitrogen, carbon or a CH group, or G is hydrogen or C1-6alkyl providing that D is nitrogen or a CH group, or G together with R forms a group W where W is (CR<16>R<17>)t where t is 2, 3 or 4 and R<16> and R<17> are independently hydrogen or C1-6alkyl or W is (CR<16>R<17>)u-J where u is 0, 1, 2 or 3 and J is oxygen, sulphur, CR<16>=CR<17>, CR<16>=N, =CR<16>O, =CR<16>S or =CR<16>-NR<17> provided that u is not 0 when J is oxygen or sulphur; X is nitrogen or carbon; R, R and R are independently hydrogen, halogen, hydroxy, C1-6alkyl, C2-6alkenyl, C3-6cycloalkyl, trifluoromethyl, C1-6alkoxy or aryl, or R together with G forms a group W as defined above; R is hydrogen or C1-6alkyl; and ------- is a single bond when X is nitrogen or a single or double bond when X is carbon; having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders.

Inventors:
Laramie Mary Guster
Application Number:
JP2000539010A
Publication Date:
March 19, 2002
Filing Date:
December 02, 1998
Export Citation:
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Assignee:
SmithKline Beecham Public Limited Company
International Classes:
C07D215/42; A61K31/496; A61K31/506; A61P25/00; A61P25/24; A61P43/00; C07D215/46; C07D401/12; C07D413/12; C07D471/04; (IPC1-7): C07D215/42; A61K31/496; A61K31/506; A61P25/00; A61P25/24; A61P43/00; C07D215/46; C07D221:00; C07D401/12; C07D413/12; C07D471/04
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)



 
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