Title:
【発明の名称】高親和性メラトニン受容体及びその使用
Document Type and Number:
Japanese Patent JP2002515003
Kind Code:
A
Abstract:
Disclosed are cDNAs and DNAs encoding high-affinity melatonin 1a and 1b receptors and the recombinant polypeptides expressed from such cDNAs. The recombinant receptor polypeptides, receptor fragments and analogs expressed on the surface of cells are used in methods of screening candidate compounds for their ability to act as agonists or antagonists to the effects of interaction between melatonin and high-affinity melatonin receptor. Agonists are used as therapeutics to reentrain endogenous melatonin rhythms as a means of treating circadian rhythm disorders in humans and control reproductive cycles in seasonally breeding animals. Antagonists are used as therapeutics to control the initiation or timing of puberty in humans. Antibodies specific for a high-affinity melatonin receptor (or receptor fragment or analog) and their use as a therapeutic are also disclosed.
Inventors:
Repertoire Stephen M
Shrimp Takashi
Shrimp Takashi
Application Number:
JP50235596A
Publication Date:
May 21, 2002
Filing Date:
June 07, 1995
Export Citation:
Assignee:
THE GENERAL HOSPITAL CORPORATION
International Classes:
C12N15/09; A61K31/40; C07K14/705; C07K14/72; C12N5/10; C12N15/12; C12N15/16; C12Q1/02; C12Q1/68; G01N33/566; A61K38/00; C07K; C12N; (IPC1-7): C07K14/705; C12N5/10; C12N15/09; C12Q1/68
Attorney, Agent or Firm:
Shimizu Hatsushi