Title:
【発明の名称】α1β1インテグリンレセプターインヒビターおよびIGF-β1インヒビターの腎臓病の治療における使用
Document Type and Number:
Japanese Patent JP2002516287
Kind Code:
A
Abstract:
The present invention provides methods for treating (i.e., delaying the onset of, slowing the progression of, and/or reversing) kidney disorders (e.g., renal glomerulonephritis and/or renal fibrosis). Certain of these methods involve administering an alpha 1 beta 1 integrin receptor inhibitor optionally in combination with a TGF- beta 1 inhibitor. The present invention also provides a mouse model for kidney disease wherein the mouse does not express a normal collagen type 4 composition in the GBM (i.e., it does not incorporate collagen alpha 3(IV), alpha (IV), and alpha 5(IV) chains into its glomerular basement membrane) and does not express the alpha 1 beta 1 integrin receptor.
Inventors:
Cosgrove, dominique
Application Number:
JP2000550500A
Publication Date:
June 04, 2002
Filing Date:
May 19, 1999
Export Citation:
Assignee:
Boys Town National Research Hospital
International Classes:
A61K31/436; A61K38/00; A61K38/39; A61K39/395; A61P13/12; A61K45/00; A61P43/00; C07K16/28; C09K3/18; (IPC1-7): A61K45/00; A61K38/00; A61K39/395; A61P13/12; A61P43/00
Foreign References:
| WO1997011718A1 | 1997-04-03 |
Attorney, Agent or Firm:
Takashi Ishida (4 others)