Title:
【発明の名称】金属介在セリンプロテアーゼインヒビター
Document Type and Number:
Japanese Patent JP2002516566
Kind Code:
A
Abstract:
The present invention relates to serine protease inhibitors having a P site binding moiety and a divalent cation(s) chelating moiety which are pre-prepared as divalent cation(s) complexes or combined with the serine protease in the presence of divalent cation(s) and methods for identifying and using the inhibitors. The compounds are shown to have high inhibitory activity when complexed to divalent cation(s) and are useful in various processes associated with serine protease isolation and inhibition.
Inventors:
Clark, James M.
Elrod, keel
Jenkins, Thomas E.
Kates, Bradley A.
Moore, William Earl.
Strood, Robert M.
Elrod, keel
Jenkins, Thomas E.
Kates, Bradley A.
Moore, William Earl.
Strood, Robert M.
Application Number:
JP52360898A
Publication Date:
June 04, 2002
Filing Date:
March 21, 1997
Export Citation:
Assignee:
Axis Pharmaceuticals, Incorporated
The Regents of the University of California
The Regents of the University of California
International Classes:
C12N9/99; A61K31/4184; A61K45/00; A61P43/00; C07D235/18; C07D235/20; C07D401/04; C07D401/06; C07D403/06; C07K14/81; C12N9/64; C12Q1/37; (IPC1-7): C12Q1/37; A61K31/4184; A61K45/00; A61P43/00; C07D235/20; C12N9/99
Attorney, Agent or Firm:
Takashi Ishida (4 others)