Title:
【発明の名称】HIVの治療薬物の製造のための他の抗HIV薬と組み合わせた3’-アジド-2’,3’-ジデオキシウリジンの使用
Document Type and Number:
Japanese Patent JP2002518452
Kind Code:
A
Abstract:
It has been discovered that 3'-azido-2',3'-dideoxyuridine (CS-87) induces a transient mutation in HIV-1 at the 70th codon (K to R, i.e., lysine to arginine) of the reverse transcriptase region of the virus. Based on this discovery, a method and composition for treating HIV is provided that includes administering CS-87 or its pharmaceutically acceptable salt or prodrug to a human in need of therapy in combination or alternation with a drug that induces a mutation in HIV-1 at a location other than the 70th codon of the reverse transcriptase region. This invention can be practiced by referring to the published mutation patterns for known anti-HIV drugs, or by determining the mutation pattern for a new drug.
Inventors:
Skinaj, Raymond
Bryant, Martin El.
Myers, Maureen W.
Bryant, Martin El.
Myers, Maureen W.
Application Number:
JP2000555622A
Publication Date:
June 25, 2002
Filing Date:
June 24, 1999
Export Citation:
Assignee:
Emori University
Nobilio Pharmaceuticals Limited
Nobilio Pharmaceuticals Limited
International Classes:
A61K31/427; A61K31/472; A61K31/4725; A61K31/496; A61K31/506; A61K31/52; A61K31/551; A61K31/70; A61K31/7072; A61K45/06; A61P31/18; A61P43/00; A61K45/00; (IPC1-7): A61K45/00; A61K31/427; A61K31/472; A61K31/4725; A61K31/496; A61K31/506; A61K31/52; A61K31/551; A61K31/7072; A61P31/18; A61P43/00
Attorney, Agent or Firm:
Takashi Ishida (4 others)