Title:
【発明の名称】腸溶性コーティング製薬錠剤及びその製法
Document Type and Number:
Japanese Patent JP2002520350
Kind Code:
A
Abstract:
A high drug load enteric coated pharmaceutical composition is provided which includes a core in the form of a tablet and which is comprised of a medicament which is sensitive to a low pH environment of less than 3, such as ddl, and having an enteric coating formed of methacrylic acid copolymer and a plasticizer. The tablets may be of varying sizes and may be orally ingested individually or a plurality of tablets sufficient to attain a desired dosage may be encapsulated in a dissolvable capsule. The tablets have excellent resistance to disintegration at pH less than 3 but have excellent drug release properties at pH greater than 4.5. A novel method of making said pharmaceutical composition is also disclosed.
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Inventors:
Ulah, Ismat
Willie, Gerry Jay
Willie, Gerry Jay
Application Number:
JP2000559831A
Publication Date:
July 09, 2002
Filing Date:
August 06, 1998
Export Citation:
Assignee:
Bristol-Myers Squibb Company
International Classes:
A61K9/20; A61K9/28; A61K9/30; A61K9/32; A61K9/52; A61K9/54; A61K9/62; A61K31/22; A61K31/522; A61K9/36; A61K31/704; A61K31/7048; A61K31/708; A61K38/46; A61K47/32; A61K47/36; A61K47/38; A61P31/12; A61K9/48; (IPC1-7): A61K9/36; A61K31/22; A61K31/522; A61K31/704; A61K31/7048; A61K31/708; A61K38/46; A61K47/32; A61K47/36; A61K47/38
Attorney, Agent or Firm:
Takehiko Saito (1 outside)