Title:
【発明の名称】心臓で組織特異的に発現する新規組換えアデノウイルス
Document Type and Number:
Japanese Patent JP2002525064
Kind Code:
A
Abstract:
The present invention relates to a human type-5 recombinant adenovirus vector for achieving cardiac restricted transcription involving utilization of the cardiomyocyte-restricted cardiac ankyrin repeat protein (CARP) promoter with inclusion of the inverted terminal repeat sequences from human adeno-associated virus (AAV). Using green fluorescent protein (GFP) as a marker gene, the recombinant adenovirus vector (Ad/CG/ITR) is shown to direct transgene expression to myocardial tissue in vivo and in vitro in mouse models.
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Inventors:
Chen, Kenneth Earl.
One, Ibin
Evans, Sylvia
One, Ibin
Evans, Sylvia
Application Number:
JP2000570348A
Publication Date:
August 13, 2002
Filing Date:
September 10, 1999
Export Citation:
Assignee:
The Legends of the Universty of California
International Classes:
A61K35/76; A61K48/00; A61P9/00; C12N15/861; C12Q1/02; C12N15/09; (IPC1-7): C12N15/09; A61K35/76; A61K48/00; A61P9/00; C12Q1/02
Attorney, Agent or Firm:
Hidekazu Miyoshi (1 outside)