Title:
【発明の名称】ホスホジエステラーゼ4阻害剤としてのベンザジン誘導体
Document Type and Number:
Japanese Patent JP2002527430
Kind Code:
A
Abstract:
Compounds of formula I:wherein A is a heterocycle containing a nitrogen atom and optionally saturated or unsaturated and optionally further substituted by an oxo group (=O); R is: hydrogen, cyano, (C1-4)alkoxycarbonyl, carbamoyl; optionally substituted (C4-7)-cycloalkyl, aryl or heterocycle; (C1-8)alkyl, (C2-8)alkenyl or (C2-8)alkynyl optionally branched and/or substituted by (C4-7) cycloalkyl, aryl or heterocycle; aryloxy, heterocyclyloxy, aryl(C1-4)alkoxy, heterocyclyl(C1-4)alkoxy, amino substituted by one or two (C1-4)alkyl group(s), aryl-amino, heterocyclyl-amino, aryl(C1-4)alkyl-amino, or heterocyclyl(C1-4)alkylamino; Y is methylene or ethylene; W is an optionally substituted aryl or heterocycle; R1 is hydrogen, (C4-7)cycloalkyl or a (C2-8)alkyl, (C2-8)alkenyl or (C2-8)alkynyl group optionally substituted by hydroxy, oxo, (C4-7)cycloalkyl, aryl or heterocycle, and optionally interrupted by one or more heteroatom(s) or heterogroup(s); R2 is a (C1-6)alkyl or polyfluoro(C1-6)alkyl group; the N->O derivatives of the compounds of formula I and the pharmaceutically acceptable salts thereof. The compounds of formula (I) are PDE 4 inhibitors and may be used in compositions and methods involving PDE 4 inhibition.
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Inventors:
Napoletano, Mauro
Gabriel Norcini
Grancini, Giancarlo
Francini, Terracini
Gabriel, Morazzoni
Pradella, Lorenzo
Gabriel Norcini
Grancini, Giancarlo
Francini, Terracini
Gabriel, Morazzoni
Pradella, Lorenzo
Application Number:
JP2000575853A
Publication Date:
August 27, 2002
Filing Date:
October 01, 1999
Export Citation:
Assignee:
Zambon Group S.P.A.
International Classes:
A61K31/4709; A61K31/4725; A61P11/00; A61P29/00; A61P37/08; A61P43/00; C07D401/06; (IPC1-7): C07D401/06; A61K31/4709; A61K31/4725; A61P11/00; A61P29/00; A61P37/08; A61P43/00
Attorney, Agent or Firm:
Miyuki Ariga (6 people outside)