Title:
【発明の名称】抗炎症活性を有する新規なイミダゾール類
Document Type and Number:
Japanese Patent JP2002527508
Kind Code:
A
Abstract:
Compounds of formula I wherein: one of X or Y represents N and the other represents C; R1 represents hydrogen, methyl, halogen, cyano, nitro, -CHO, -COCH3 or -COOR4; R2 represents optionally-substituted aryl or heteroaryl; R3 represents C1-8 alkyl, C1-8 haloalkyl or -NR4R6; R4 represents hydrogen, C1-8 alkyl or arylC0-8 alkyl; R6 represents hydrogen, C1-8 alkyl, arylC1-8 alkyl, -COR8 or -COOR8; R8 represents C1-8 alkyl or C1-8 haloalkyl; aryl in the above definitions represents phenyl or naphthyl; and heteroaryl in the above definitions represents pyridine, pyrazine, pyrimidine or pyridazine, which can be optionally fused to a benzene ring. These compounds are useful as cyclooxygenase-2 inhibitors.
Inventors:
Carmen, Almansa
Concepcion, Gonzales
Ma, Carmen, Torres
Concepcion, Gonzales
Ma, Carmen, Torres
Application Number:
JP2000577154A
Publication Date:
August 27, 2002
Filing Date:
October 15, 1999
Export Citation:
Assignee:
J.URIACH & CIA, S.A.
International Classes:
C07D233/60; A61K31/4164; A61K31/4427; A61K31/4439; A61P1/00; A61P9/10; A61P11/00; A61P11/06; A61P15/00; A61P21/02; A61P25/08; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07D233/54; C07D233/64; C07D233/68; C07D233/90; C07D401/04; (IPC1-7): C07D233/60; A61P1/00; A61P9/10; A61P11/00; A61P11/06; A61P15/00; A61P21/02; A61P25/08; A61P25/28; A61P29/00; A61P35/00; A61P43/00; C07D233/64; C07D233/68; C07D233/90; C07D401/04
Domestic Patent References:
| JPS5849369A | 1983-03-23 | |||
| JPH10503211A | 1998-03-24 |
Attorney, Agent or Firm:
Kenji Yoshitake (3 others)