Title:
【発明の名称】アミロイド症を変調する方法及び組成物
Document Type and Number:
Japanese Patent JP2002528411
Kind Code:
A
Abstract:
Methods for modulating amyloid deposition in a subject are described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to a subject, such that modulation of amyloid deposition occurs. Methods also include administering and effective amount of at least one ABC transporter blocker, or a pharmaceutically acceptable salt thereof, to a subject such that a disease state associated with amyloidosis is treated. Packaged pharmaceutical compositions for treating amyloidosis are described. The package includes a container for holding an effective amount of a pharmaceutical composition and instructions for using the pharmaceutical composition for treatment of amyloidosis. The pharmaceutical composition includes at least one ABC blocker for modulating amyloid deposition in a subject. Methods for identifying agents which modulate amyloid deposition in a subject are also described. An effective amount of at least one ATP binding cassette (ABC) transporter blocker is administered to an organism, such that modulation of amyloid deposition occurs.
Inventors:
Rainer Peter Bee.
Lamb Fred Chiurai
Lamb Fred Chiurai
Application Number:
JP2000578000A
Publication Date:
September 03, 2002
Filing Date:
October 14, 1999
Export Citation:
Assignee:
The University of British Columbia
International Classes:
G01N33/50; A61K31/00; A61K31/138; A61K31/277; A61K31/352; A61K31/4045; A61K31/407; A61K31/436; A61K31/439; A61K31/444; A61K31/4545; A61K31/46; A61K31/4706; A61K31/473; A61K31/475; A61K31/49; A61K31/496; A61K31/53; A61K31/5415; A61K31/573; A61K38/13; A61K45/00; A61P25/00; A61P25/28; A61P43/00; G01N33/15; (IPC1-7): A61K45/00; A61K31/573; A61P25/00; A61P25/28; A61P43/00; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Tsutomu Kanakubo