Title:
【発明の名称】蛋白質の形質導入システムおよびその使用法
Document Type and Number:
Japanese Patent JP2002531113
Kind Code:
A
Abstract:
The present invention provides a protein transduction system comprising one or more fusion proteins that includes a transduction domain and a cytotoxic domain. The cytotoxic domain is specifically activated in a cell exhibiting a unique characteristic. Further provided are protein transduction domains that provide enhanced transduction efficiency. The protein transduction system effectively kills or injures cells infected by one or a combination of different pathogens or cells exhibiting unique characteristics such as high levels of heavy metals, DNA damage or uncontrolled cell division.
Inventors:
Stephen F. Doody
Application Number:
JP2000586751A
Publication Date:
September 24, 2002
Filing Date:
December 10, 1999
Export Citation:
Assignee:
University of Washington
International Classes:
C12N15/09; A61K9/12; A61K31/145; A61K31/522; A61K31/7068; A61K31/708; A61K38/00; A61K38/21; A61K38/55; A61K39/00; A61K39/04; A61K39/106; A61K48/00; A61P31/00; A61P31/10; A61P31/12; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P43/00; C07K7/06; C07K14/16; C07K14/47; C07K19/00; C12N5/07; C12N5/071; C12Q1/37; (IPC1-7): C12N15/09; A61K9/12; A61K31/145; A61K31/522; A61K31/7068; A61K31/708; A61K38/00; A61K38/21; A61K38/55; A61K39/00; A61K39/04; A61K39/106; A61K48/00; A61P31/00; A61P31/10; A61P31/12; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P43/00; C07K7/06; C07K14/47; C07K19/00; C12N5/06; C12Q1/37
Attorney, Agent or Firm:
Norio Saeki