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Title:
【発明の名称】血管形成阻害剤としてのキナゾリン誘導体
Document Type and Number:
Japanese Patent JP2002536414
Kind Code:
A
Abstract:
The invention relates to the use of compounds of the formula I: wherein ring C is an 8, 9, 10, 12 or 13-membered bicyclic or tricyclic moiety which optionally may contain 1-3 heteroatoms selected independently from O, N and S; Z is -O-, -NH-, -S-, -CH 2 - or a direct bond; n is 0-5; m is 0-3; R 2 represents hydrogen, hydroxy, halogeno, cyano, nitro, trifluoromethyl, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 alkylsulphanyl, -NR 3 R 4 (wherein R 3 and R 4 , which may be the same or different, each represents hydrogen or C 1-3 alkyl), or R 5 X 1 - (wherein X 1 and R 5 are as defined herein; R 1 represents hydrogen, oxo, halogeno, hydroxy, C 1-4 alkoxy, C 1-4 alkyl, C 1-4 alkoxymethyl, C 1-4 alkanoyl, C 1-4 haloalkyl, cyano, amino, C 2-5 alkenyl, C 2-5 alkynyl, C 1-3 alkanoyloxy, nitro, C 1-4 alkanoylamino, C 1-4 alkoxycarbonyl, C 1-4 alkylsulphanyl, C 1-4 alkylsulphinyl, C 1-4 alkylsulphonyl, carbamoyl, N- C 1-4 alkylcarbamoyl, N , N -di(C 1-4 alkyl)carbamoyl, aminosulphonyl, N -C 1-4 alkylaminosulphonyl, N , N -di(C 1-4 alkyl)ammosulphonyl, N -(C 1-4 alkylsulphonyl)amino, N- (C 1-4 alkylsulphonyl)- N -(C 1-4 alkyl)amino, N , N -di(C 1-4 alkylsulphonyl)amino, a C 3-7 alkylene chain joined to two ring C carbon atoms, C 1-4 alkanoylaminoC 1-4 alkyl, carboxy or a group R 56 X 10 (wherein X 10 and R 56 are as defined herein); and salts thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals, processes for the preparation of such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and compounds of formula I. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.

Inventors:
Laurent Francois Andre, Enecan
Pre, patrick
Stokes, Elaine Sophie Elizabeth
McAlleshire, Darren
Application Number:
JP2000598164A
Publication Date:
October 29, 2002
Filing Date:
February 08, 2000
Export Citation:
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Assignee:
AstraZeneca Activrag
International Classes:
A61K31/505; A61K31/517; A61K31/5377; A61K31/541; A61P3/10; A61P9/00; A61P13/00; A61P13/12; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P37/00; C07D209/08; C07D239/72; C07D239/88; C07D239/94; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/12; C07D405/14; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D521/00; (IPC1-7): C07D239/88; A61K31/517; A61K31/5377; A61K31/541; A61P3/10; A61P9/00; A61P13/00; A61P13/12; A61P17/06; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P37/00; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/14; C07D417/14
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)



 
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