Title:
【発明の名称】キシロ-LNA類似体
Document Type and Number:
Japanese Patent JP2002540118
Kind Code:
A
Abstract:
A bicyclic nucleoside derivative, wherein an intranucleoside ring locks the ring conformation of the nucleoside, is termed an LNA - a Locked Nucleic Acid. LNAs of the xylo-configuration, considered useful as therapeutic agents, diagnostic agents and useful for the formation of oligonucleotides, have been prepared. These oligonucleotides are also useful as a therapeutic and in diagnostic fields. Furthermore, oligonucleotides comprising LNAs of the xylo-configuration are useful for high-affinity targeting of complementary single stranded and double stranded DNA and RNA and have interesting activity with regards to specificity and affinity to oligonucleotides.
Inventors:
Jesper Wenger
Application Number:
JP2000606609A
Publication Date:
November 26, 2002
Filing Date:
March 17, 2000
Export Citation:
Assignee:
Exicon D/S
International Classes:
G01N33/53; A61K31/7088; A61K48/00; A61P31/12; A61P35/00; A61P43/00; C07H19/06; C07H19/10; C07H19/16; C07H21/00; C12N15/09; C12Q1/02; C12Q1/68; G01N33/566; (IPC1-7): C07H19/06; A61K31/7088; A61K48/00; A61P31/12; A61P35/00; A61P43/00; C07H19/16; C07H21/00; C12N15/09; C12Q1/02; C12Q1/68; G01N33/53; G01N33/566
Domestic Patent References:
| JPH10304889A | 1998-11-17 |
Attorney, Agent or Firm:
Norio Saeki