Title:
【発明の名称】ヒトIL-12に結合するヒト抗体およびその産生法
Document Type and Number:
Japanese Patent JP2002542770
Kind Code:
A
Abstract:
Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the inveniton are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.
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Inventors:
Salfurt, Johen Geh
Rogaska, Michael
Perth Kind, Michael
Banergie, Subhasis
Tracy, Daniel Yee
White, michael
Kaimak Jiyaran, Zephyr
Ravkovsky, Boris
Sakorafasu, paul
Friedrich, Stiletto
Miles, Anjiera
Felt Man, Hale Trida Em
Venteurini, Amii
Warne, Nicholas Dobrieu
Widom, Angiela
Elvin, John Gee
Duncan, Alexander Earl
Derbyshire, Elaine J.A.
Carmen, sara
Smith, stephen
Holted, Thor Russ
Sarah El
Rogaska, Michael
Perth Kind, Michael
Banergie, Subhasis
Tracy, Daniel Yee
White, michael
Kaimak Jiyaran, Zephyr
Ravkovsky, Boris
Sakorafasu, paul
Friedrich, Stiletto
Miles, Anjiera
Felt Man, Hale Trida Em
Venteurini, Amii
Warne, Nicholas Dobrieu
Widom, Angiela
Elvin, John Gee
Duncan, Alexander Earl
Derbyshire, Elaine J.A.
Carmen, sara
Smith, stephen
Holted, Thor Russ
Sarah El
Application Number:
JP2000606632A
Publication Date:
December 17, 2002
Filing Date:
March 24, 2000
Export Citation:
Assignee:
Knorr GMBH
The Energy Cusx Instate ULC
The Energy Cusx Instate ULC
International Classes:
G01N33/53; A61K39/395; A61P1/04; A61P1/16; A61P3/10; A61P5/16; A61P7/00; A61P7/02; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/14; A61P11/00; A61P11/06; A61P11/16; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/08; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P31/00; A61P31/04; A61P31/18; A61P33/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07K16/24; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/02; C12N15/13; C12P21/08; (IPC1-7): C12N15/02; A61K39/395; A61P1/04; A61P1/16; A61P3/10; A61P5/16; A61P7/00; A61P7/02; A61P7/04; A61P7/06; A61P9/00; A61P9/04; A61P9/10; A61P9/14; A61P11/00; A61P11/06; A61P11/16; A61P13/12; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/08; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P31/00; A61P31/04; A61P31/18; A61P33/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07K16/24; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/08; G01N33/53
Attorney, Agent or Firm:
Yoshio Kawaguchi (5 outside)