Title:
【発明の名称】C17アルキル側鎖および芳香族A環をもつ治療に使用するステロイド化合物
Document Type and Number:
Japanese Patent JP2002544137
Kind Code:
A
Abstract:
Formula (I) in which: R1 and R2, which may be the same or different, each represents a lower alkyl, alkenyl or alkynyl group; R3 represents a methyl group having alpha- or beta-configuration; R4 represents a hydrogen atom or an etherifying or esterifying group; R5 represents a hydrogen atom, a hydroxyl group or a lower alkoxy group; X represents a group OR4, or a group NR6R7 wherein R6 represents a hydrogen atom, an aliphatic or araliphatic group, or an acyl group comprising an aliphatic, araliphatic or aryl group linked to the nitrogen atom by way of a carbonyl group; and R7 is a hydrogen atom or a lower alkyl group; Y represents a lower alkylene, alkenylene or alkynylene group optionally substituted by a hydroxyl, etherified hydroxyl or esterified hydroxyl group; exhibit potent effects on modulation of cell growth and differentiation, while having low calcaemic activity.
Inventors:
Robert Henry Hess
Sundara Categum Srinivasa Seti Seti
Marathi Ramgopal
Sanga Couga Balsorrier
Sundara Categum Srinivasa Seti Seti
Marathi Ramgopal
Sanga Couga Balsorrier
Application Number:
JP2000616220A
Publication Date:
December 24, 2002
Filing Date:
May 11, 2000
Export Citation:
Assignee:
Research Institute for Medicine and Chemistry Incorporated
International Classes:
A61P1/00; A61P3/06; A61P5/00; A61P5/02; A61P5/20; A61P7/02; A61P9/10; A61P9/12; A61P11/06; A61P15/08; A61P15/18; A61P17/00; A61P17/02; A61P19/00; A61P19/02; A61P19/08; A61P21/00; A61P25/28; A61P29/00; A61K31/575; A61P35/00; A61P37/02; A61P37/06; C07J9/00; C07J41/00; C07J51/00; (IPC1-7): C07J41/00; A61K31/575; A61P1/00; A61P5/00; A61P5/02; A61P7/02; A61P9/12; A61P11/06; A61P15/08; A61P17/00; A61P17/02; A61P19/00; A61P19/02; A61P19/08; A61P21/00; A61P25/28; A61P29/00; A61P35/00; A61P37/02
Domestic Patent References:
| JPH01229000A | 1989-09-12 | |||
| JPH01229000A | 1989-09-12 |
Other References:
JPN6010050710, ＤＯＬＥＮＣＥ， Ｅ． Ｋ．, "Ａ ｓｔｅｒｅｏｓｅｌｅｃｔｉｖｅ ｓｙｎｔｈｅｓｉｓ ｏｆ １，２−ｄｉｏｌｓ ｆｒｏｍ α−ｈｙｄｒｏｘｙａｌｄｅｈｙｄｅｓ", Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ, 1985, ２６（９）, ｐ． １１８９−１１９２
JPN6010050711, ＬＡＪＥＵＮＥＳＳＥ， Ｄ．, "Ｅｆｆｅｃｔ ｏｆ １７β−ｅｓｔｒａｄｉｏｌ ｏｎ ｔｈｅ ｈｕｍａｎ ｏｓｔｅｏｓａｒｃｏｍａ ｃｅｌｌ ｌｉｎｅ ＭＧ−６３", Ｂｏｎｅ ａｎｄ Ｍｉｎｅｒａｌ, 1994, ２４（１）, ｐ． １−１６
JPN6010050711, ＬＡＪＥＵＮＥＳＳＥ， Ｄ．, "Ｅｆｆｅｃｔ ｏｆ １７β−ｅｓｔｒａｄｉｏｌ ｏｎ ｔｈｅ ｈｕｍａｎ ｏｓｔｅｏｓａｒｃｏｍａ ｃｅｌｌ ｌｉｎｅ ＭＧ−６３", Ｂｏｎｅ ａｎｄ Ｍｉｎｅｒａｌ, 1994, ２４（１）, ｐ． １−１６
Attorney, Agent or Firm:
Chika Takagi (2 outside)
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