Title:
【発明の名称】固体組織中の内因性ヌクレオチド配列を変化させるためのキメラ突然変異ベクターの使用
Document Type and Number:
Japanese Patent JP2003502288
Kind Code:
A
Abstract:
This invention relates to the field of muscular dystrophy and methods for its treatment in humans. This invention also concerns art-recognized animal models of Duchenne muscular dystrophy in dogs (GRMD) and mice (mdx). Another aspect concerns chimeric mutational vectors capable of inducing reversion of genetic mutations (i.e., gene repair) causing genetic disease by direct injection into affected tissue. Thus, more generally, the invention envisions direct injection of chimeric mutational vectors into affected tissues to effect gene repair therein.
Inventors:
Bartlett, Richard, Jay
Landor, Thomas, A
Landor, Thomas, A
Application Number:
JP2000619466A
Publication Date:
January 21, 2003
Filing Date:
May 19, 2000
Export Citation:
Assignee:
The University of Miami
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Barrett, Richard, Jay.
Land-, Thomas, A.
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Barrett, Richard, Jay.
Land-, Thomas, A.
International Classes:
C12N15/09; A61K31/7088; A61K39/395; A61K47/44; A61K47/48; A61K48/00; A61P21/02; C12N15/01; C12N15/90; (IPC1-7): A61K48/00; A61K31/7088; A61K39/395; A61K47/44; A61K47/48; A61P21/02; C12N15/01; C12N15/09
Attorney, Agent or Firm:
Akira Asamura (3 outside)