Title:
【発明の名称】細胞接着の阻害剤としての置換プリン誘導体
Document Type and Number:
Japanese Patent JP2003503497
Kind Code:
A
Abstract:
The present invention relates to compounds of the formula I, in which B, D, E, G, X, Y, Z, R<1>, R<2> and s have the meanings indicated in the claims, their physiologically tolerable salts and their prodrugs. The compounds of the formula I are valuable pharmacologically active compounds. They are vitronectin receptor antagonists and inhibitors of cell adhesion and are suitable for the therapy and prophylaxis of illnesses which are based on the interaction between vitronectin receptors and their ligands in cell-cell or cell-matrix interaction processes or which can be prevented, alleviated or cured by influencing such interactions. For example, they can be applied for inhibiting bone resorption by osteoclasts and thus for treating and preventing osteoporosis, or for inhibiting undesired angiogenesis or proliferation of cells of the vascular smooth musculature. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.
Inventors:
Anusylvan Payman
Jochen Knorr
Thomas Earl Gadek
Jean Francois Ghoul Vest
Jean Marie Ryugze
Jochen Knorr
Thomas Earl Gadek
Jean Francois Ghoul Vest
Jean Marie Ryugze
Application Number:
JP2001507836A
Publication Date:
January 28, 2003
Filing Date:
June 26, 2000
Export Citation:
Assignee:
Aventis Pharma Deutscher Gamebeer
GENENTECH,INC.
GENENTECH,INC.
International Classes:
A61K31/52; A61P1/02; A61P3/14; A61P5/24; A61P19/00; A61P19/10; A61P29/00; A61P43/00; C07D473/34; (IPC1-7): C07D473/34; A61K31/52; A61P1/02; A61P3/14; A61P5/24; A61P19/00; A61P19/10; A61P29/00; A61P43/00
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)
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