Title:
【発明の名称】カルボン酸アミド、その調製法及び医薬組成物としてのその使用
Document Type and Number:
Japanese Patent JP2003506432
Kind Code:
A
Abstract:
The present invention relates to carboxylic acid amides of general formula wherein R1 to R5, Ar, m and n are defined as in claim 1 , the tautomers, stereoisomers, mixtures thereof, the prodrugs and the salts thereof which have valuable properties. The compounds of the above general formula I wherein R5 denotes a cyano group are valuable intermediate products for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein R5 denotes one of the amidino groups mentioned in claim 1 have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.
Inventors:
Lies Uwe
Prepke Henning
Heckel Armin
Naru Herbert
Wienen Wolfgang
Stassen Yarn Marie
Prepke Henning
Heckel Armin
Naru Herbert
Wienen Wolfgang
Stassen Yarn Marie
Application Number:
JP2001515290A
Publication Date:
February 18, 2003
Filing Date:
August 02, 2000
Export Citation:
Assignee:
Boehringer Ingelheim Pharma Comandito Gezelshaft
International Classes:
C07D295/18; A61K31/167; A61K31/18; A61K31/40; A61K31/4164; A61K31/4453; A61P7/02; A61P43/00; C07C257/18; C07C303/40; C07C311/21; C07C311/46; C07D207/12; C07D211/46; C07D213/68; C07D233/54; C07D295/12; C07D295/135; C07D295/185; C07D295/192; (IPC1-7): C07C257/18; A61K31/167; A61K31/18; A61K31/40; A61K31/4453; A61P7/02; A61P43/00; C07C303/40; C07C311/46; C07D207/12; C07D295/18
Attorney, Agent or Firm:
Minoru Nakamura (9 outside)