Title:
【発明の名称】血管形成阻害活性をもつ置換ピリダジン類および縮合ピリダジン類
Document Type and Number:
Japanese Patent JP2003506447
Kind Code:
A
Abstract:
Substituted and fused pyridazines having angiogenesis inhibiting activity and generalized structural formula (I) wherein the ring containing A, B, D, E, and L is a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R<1> and R<2> may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermeability processes using these materials are also disclosed.
Inventors:
Domus, Jack Pee
Hatum-Mokdad, Holia N
Jyo, Teddy Kite
Kruender, Harold Sea Yi
Lee, Wendy
Nagaratnam, Danaparan
Sibley, Robert N
Sue, Ning
Boyer, Stephen The Ames
Hatum-Mokdad, Holia N
Jyo, Teddy Kite
Kruender, Harold Sea Yi
Lee, Wendy
Nagaratnam, Danaparan
Sibley, Robert N
Sue, Ning
Boyer, Stephen The Ames
Application Number:
JP2001515668A
Publication Date:
February 18, 2003
Filing Date:
August 08, 2000
Export Citation:
Assignee:
BAYER CORPORATION
International Classes:
A61K31/502; A61P9/14; A61P17/00; A61P17/06; A61P19/00; A61P27/06; A61P29/00; A61P35/00; C07D401/06; C07D401/12; C07D401/14; C07D417/12; C07D417/14; (IPC1-7): C07D401/06; A61K31/502; A61P17/00; A61P17/06; A61P19/00; A61P27/06; A61P29/00; A61P35/00; C07D401/12; C07D401/14; C07D417/12
Domestic Patent References:
| JPH03106875A | 1991-05-07 | |||
| JPS4839944B1 | 1973-11-28 | |||
| JPH08225541A | 1996-09-03 | |||
| JPH0673022A | 1994-03-15 | |||
| JP2002541108A | 2002-12-03 |
Foreign References:
| WO1998035958A1 | 1998-08-20 |
Attorney, Agent or Firm:
Heiyoshi Odashima