Title:
【発明の名称】Aβタンパク質の産生阻害剤としてのヒドロキシアルカノイルアミノラクタムおよび関連構造体
Document Type and Number:
Japanese Patent JP2003509411
Kind Code:
A
Abstract:
This invention relates to novel lactams having formula (I) to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A beta -peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to beta -amyloid production such as Alzheimer's disease and Down's Syndrome.
Inventors:
Richard Eric Olson
Hong Ryu
Laurin Andrew Thompson The Third
Hong Ryu
Laurin Andrew Thompson The Third
Application Number:
JP2001523377A
Publication Date:
March 11, 2003
Filing Date:
September 13, 2000
Export Citation:
Assignee:
DuPont Pharmaceuticals Company
International Classes:
A61K31/55; A61K31/5513; A61P25/28; A61P43/00; C07D223/12; C07D223/18; C07D243/24; C07D243/26; C07D401/04; C07D401/06; C07D403/04; C07D405/12; C07D417/04; C07D243/14; (IPC1-7): C07D223/12; A61K31/55; A61K31/5513; A61P25/28; A61P43/00; C07D243/14; C07D243/26; C07D401/04; C07D401/06; C07D403/04; C07D405/12; C07D417/04
Attorney, Agent or Firm:
Yoshikazu Tani (2 outside)