Title:
【発明の名称】ヘッジホッグシグナル伝達経路のメディエーター、組成物及びそれらと関連する利用
Document Type and Number:
Japanese Patent JP2003509414
Kind Code:
A
Abstract:
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function by contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize hedgehog activity.
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Inventors:
David Antony Baxter
Edward Andrew Boyd
Oybin M. Gishart
Steven Price
Lee Dee Rubin
Edward Andrew Boyd
Oybin M. Gishart
Steven Price
Lee Dee Rubin
Application Number:
JP2001523380A
Publication Date:
March 11, 2003
Filing Date:
September 15, 2000
Export Citation:
Assignee:
Curis Incorporated
International Classes:
A61K31/165; A61K31/166; A61K31/505; A61K31/517; A61P1/02; A61P1/16; A61P1/18; A61P17/00; A61P17/02; A61P17/06; A61P17/14; A61P19/00; A61P19/02; A61P27/02; A61P27/12; A61P35/00; A61P37/08; C07D239/00; C07D239/36; C07D239/91; C07D401/12; C07D403/06; C07D405/12; C07D471/04; C12N5/07; C12N5/071; (IPC1-7): C07D239/36; A61K31/165; A61K31/166; A61K31/517; A61P1/02; A61P1/16; A61P1/18; A61P17/00; A61P17/02; A61P17/06; A61P17/14; A61P19/00; A61P19/02; A61P27/02; A61P27/12; A61P35/00; A61P37/08; C07D401/12; C07D403/06; C07D405/12; C12N5/06
Domestic Patent References:
| JPS57118570A | 1982-07-23 |
Foreign References:
| WO1999020298A1 | 1999-04-29 | |||
| US5756502A | 1998-05-26 |
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)