Title:
【発明の名称】細胞内原核生物、DNAウイルス及びレトロウイルスによる感染を治療するための、3-ヒドロキシ-4-ピロンのガリウム錯体
Document Type and Number:
Japanese Patent JP2003510362
Kind Code:
A
Abstract:
Methods are provided for treating or preventing infections by obligate intracellular prokaryotes, including mycoplasma, rickettsia and chlamydia, and DNA viruses, including herpes viruses, papillomaviruses, adenoviruses and hepatitis B virus. The methods involve the administration of 3:1 complexes of 3-hydroxy-4-pyrones with gallium, e.g., gallium maltolate. Therapies incorporating gallium maltolate in combination with agents used against obligate intracellular prokaryote and DNA virus pathogens are also provided, as are multi-combination therapies designed to treat co-infection by an obligate intracellular prokaryote or DNA virus in an immunocompromised individual. These multi-combination therapies rely on the ability of gallium maltolate to complement antiviral medication regimes against both HIV and other pathogens such as herpesvirus infections, including Kaposi sarcoma, CMV retinitis and blindness, and lymphomas, in patients immunocompromised by HIV infection.
Inventors:
Lawrence Earl Bernstein
Application Number:
JP2001527798A
Publication Date:
March 18, 2003
Filing Date:
October 04, 2000
Export Citation:
Assignee:
Lawrence Earl Bernstein
International Classes:
A61K47/48; A61K31/522; A61K31/555; A61K31/7068; A61K31/7072; A61K31/7076; A61K33/24; A61K38/55; A61K45/06; A61P31/12; A61P31/18; A61P31/22; A61P43/00; (IPC1-7): A61K33/24; A61K31/522; A61K31/7068; A61K31/7072; A61K31/7076; A61K47/48; A61P31/12; A61P31/18; A61P31/22; A61P43/00
Attorney, Agent or Firm:
Masatake Shiga (7 outside)