Title:
【発明の名称】原発性胆汁性肝硬変および自己免疫障害に関連する新規レトロウイルスの同定
Document Type and Number:
Japanese Patent JP2003512023
Kind Code:
A
Abstract:
The present invention relates, first, to the discovery, identification, and characterization of novel nucleic acid molecules, that are associated with PBC, Sjögren's syndrome, scleroderma, SLE, autoimmune thyroiditis and various other connective tissue disorders. The novel nucleotide sequences of the present invention are retroviral in origin and are indicative of a PBC retrovirus which bears a strong correlation with PBC. The present invention is based, in part, on the Applicant's data which is the first evidence to suggest that PBC patient's tissue may harbor a transmissible agent. The association of a retroviral infectious agent with PBC was first demonstrated by Applicants in vitro by co-culture of periportal lymph nodes derived from patients at time of transplantation and healthy biliary epithelium cells. The Applicant's discoveries as described herein, report the characterization of PBC-associated infectious agent as retroviral as demonstrated by electron microscopy and immunoblot reactivity. In addition, Applicants have characterized novel nucleotide sequences which are associated with the PBC-associated retrovirus.
Inventors:
Mason, Andrew, Elle.
Sue Rize
James, Neuburger
Sue Rize
James, Neuburger
Application Number:
JP2001500816A
Publication Date:
April 02, 2003
Filing Date:
June 01, 2000
Export Citation:
Assignee:
Alton Okesner Medical Foundation
International Classes:
G01N33/569; A61K31/7088; A61K45/00; A61K48/00; A61P1/16; A61P5/14; A61P17/00; A61P29/00; A61P31/12; A61P37/02; A61P37/06; C07K14/15; C12N7/00; C12N15/09; C12Q1/68; C12Q1/70; A61K39/00; (IPC1-7): C12N15/09; A61K31/7088; A61K45/00; A61K48/00; A61P1/16; A61P5/14; A61P17/00; A61P29/00; A61P31/12; A61P37/02; A61P37/06; C12Q1/68; G01N33/569
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)