Title:
【発明の名称】腺維芽細胞成長受容体-3又は-2を発現する細胞を標的化するための方法
Document Type and Number:
Japanese Patent JP2003515567
Kind Code:
A
Abstract:
Fibroblast growth factor-18 (FGF-18) binds with FGF receptors-2 and -3. Compositions comprising an FGF-18 component can be used to target cells that express these receptors. Suitable targets include tumor cells that express constitutively activated forms of FGF receptors-2 and -3.
Inventors:
West, James W.
Application Number:
JP2001541520A
Publication Date:
May 07, 2003
Filing Date:
November 28, 2000
Export Citation:
Assignee:
Zymogenetics, Incorporated
International Classes:
A61K45/00; A61K38/00; A61K38/18; A61K47/48; A61P35/00; C07K14/50; (IPC1-7): A61K38/00; A61K45/00; A61P35/00; C07K14/50
Foreign References:
| US5911995A | 1999-06-15 | |||
| US5911995A | 1999-06-15 |
Other References:
JPN6010060750; Ｌａｐｐｉ ＤＡ．: 'Ｔｕｍｏｒ ｔａｒｇｅｔｉｎｇ ｔｈｒｏｕｇｈ ｆｉｂｒｏｂｌａｓｔ ｇｒｏｗｔｈ ｆａｃｔｏｒ ｒｅｃｅｐｔｏｒｓ．' Ｓｅｍｉｎ Ｃａｎｃｅｒ Ｂｉｏｌ． ６巻５号, 199510, ｐｐ．２７９-２８８
JPN6010060752; Ｏｈｂａｙａｓｈｉ Ｎ ｅｔ ａｌ．: 'Ｓｔｒｕｃｔｕｒｅ ａｎｄ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｔｈｅ ｍＲＮＡ ｅｎｃｏｄｉｎｇ ａ ｎｏｖｅｌ ｆｉｂｒｏｂｌａｓｔ ｇｒｏｗｔｈ ｆａｃｔｏｒ， ＦＧＦ-１８．' Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２７３巻２９号, 19980717, ｐｐ．１８１６１-１８１６４
JPN6010060753; Ｐａｓｔａｎ Ｉ ｅｔ ａｌ．: 'Ｉｍｍｕｎｏｔｏｘｉｎｓ' Ｃｅｌｌ ４７巻５号, 19861205, ｐｐ．６４１-６４８
JPN6010060755; Ｇｏｌｄｅｎｂｅｒｇ ＤＭ．: 'Ｎｅｗ ｄｅｖｅｌｏｐｍｅｎｔｓ ｉｎ ｍｏｎｏｃｌｏｎａｌ ａｎｔｉｂｏｄｉｅｓ ｆｏｒ ｃａｎｃｅｒ ｄｅｔｅｃｔｉｏｎ ａｎｄ ｔｈｅｒａｐｙ．' ＣＡ Ｃａｎｃｅｒ Ｊ Ｃｌｉｎ． ４４巻１号, 199402, ｐｐ．４３-６４
JPN6010060756; Ｍｕｒａｈａｓｈｉ Ｎ ｅｔ ａｌ．: 'Ｈｅｐａｔｉｃ ａｃｃｕｍｕｌａｔｉｏｎ ｏｆ ｇｌｕｔａｍｉｃ ａｃｉｄ ｂｒａｎｃｈｅｄ ｎｅｏｇａｌａｃｔｏｓｙｌｌｉｐｉｄ ｍｏｄｉｆｉｅｄ ｌｉｐｏｓｏｍｅｓ．' Ｂｉｏｌ Ｐｈａｒｍ Ｂｕｌｌ． ２０巻３号, 199703, ｐｐ．２５９-２６６
JPN6011063895; ＭａｃＡｒｔｈｕｒ ＣＡ ｅｔ ａｌ．: 'ＦＧＦ-８ ｉｓｏｆｏｒｍｓ ａｃｔｉｖａｔｅ ｒｅｃｅｐｔｏｒ ｓｐｌｉｃｅ ｆｏｒｍｓ ｔｈａｔ ａｒｅ ｅｘｐｒｅｓｓｅｄ ｉｎ ｍｅｓｅｎｃｈｙｍａｌ ｒｅｇｉｏｎｓ ｏｆ ｍｏｕｓｅ ｄｅｖ' Ｄｅｖｅｌｏｐｍｅｎｔ Ｖｏｌ．１２１ ｎｏ．１１, 199511, ｐｐ．３６０３-３６１３
JPN6011063896; Ｍａｒｓｈ ＳＫ ｅｔ ａｌ．: 'Ｉｎｃｒｅａｓｅｄ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｆｉｂｒｏｂｌａｓｔ ｇｒｏｗｔｈ ｆａｃｔｏｒ ８ ｉｎ ｈｕｍａｎ ｂｒｅａｓｔ ｃａｎｃｅｒ．' Ｏｎｃｏｇｅｎｅ． Ｖｏｌ．１８ ｎｏ．４, 199901, ｐｐ．１０５３-１０６０
JPN6011063897; Ｃｈｅｓｉ Ｍ ｅｔ ａｌ．: 'Ｔｈｅ ｔ（４；１４） ｔｒａｎｓｌｏｃａｔｉｏｎ ｉｎ ｍｙｅｌｏｍａ ｄｙｓｒｅｇｕｌａｔｅｓ ｂｏｔｈ ＦＧＦＲ３ ａｎｄ ａ ｎｏｖｅｌ ｇｅｎｅ， ＭＭＳＥＴ， ｒｅｓｕｌｔｉｎｇ ｉｎ Ｉ' Ｂｌｏｏｄ． Ｖｏｌ．９２ ｎｏ．９, 19981101, ｐｐ．３０２５-３０３４
JPN6010060750; Ｌａｐｐｉ ＤＡ．: 'Ｔｕｍｏｒ ｔａｒｇｅｔｉｎｇ ｔｈｒｏｕｇｈ ｆｉｂｒｏｂｌａｓｔ ｇｒｏｗｔｈ ｆａｃｔｏｒ ｒｅｃｅｐｔｏｒｓ．' Ｓｅｍｉｎ Ｃａｎｃｅｒ Ｂｉｏｌ． ６巻５号, 199510, ｐｐ．２７９-２８８
JPN6010060752; Ｏｈｂａｙａｓｈｉ Ｎ ｅｔ ａｌ．: 'Ｓｔｒｕｃｔｕｒｅ ａｎｄ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｔｈｅ ｍＲＮＡ ｅｎｃｏｄｉｎｇ ａ ｎｏｖｅｌ ｆｉｂｒｏｂｌａｓｔ ｇｒｏｗｔｈ ｆａｃｔｏｒ， ＦＧＦ-１８．' Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２７３巻２９号, 19980717, ｐｐ．１８１６１-１８１６４
JPN6010060753; Ｐａｓｔａｎ Ｉ ｅｔ ａｌ．: 'Ｉｍｍｕｎｏｔｏｘｉｎｓ' Ｃｅｌｌ ４７巻５号, 19861205, ｐｐ．６４１-６４８
JPN6010060755; Ｇｏｌｄｅｎｂｅｒｇ ＤＭ．: 'Ｎｅｗ ｄｅｖｅｌｏｐｍｅｎｔｓ ｉｎ ｍｏｎｏｃｌｏｎａｌ ａｎｔｉｂｏｄｉｅｓ ｆｏｒ ｃａｎｃｅｒ ｄｅｔｅｃｔｉｏｎ ａｎｄ ｔｈｅｒａｐｙ．' ＣＡ Ｃａｎｃｅｒ Ｊ Ｃｌｉｎ． ４４巻１号, 199402, ｐｐ．４３-６４
JPN6010060756; Ｍｕｒａｈａｓｈｉ Ｎ ｅｔ ａｌ．: 'Ｈｅｐａｔｉｃ ａｃｃｕｍｕｌａｔｉｏｎ ｏｆ ｇｌｕｔａｍｉｃ ａｃｉｄ ｂｒａｎｃｈｅｄ ｎｅｏｇａｌａｃｔｏｓｙｌｌｉｐｉｄ ｍｏｄｉｆｉｅｄ ｌｉｐｏｓｏｍｅｓ．' Ｂｉｏｌ Ｐｈａｒｍ Ｂｕｌｌ． ２０巻３号, 199703, ｐｐ．２５９-２６６
JPN6011063895; ＭａｃＡｒｔｈｕｒ ＣＡ ｅｔ ａｌ．: 'ＦＧＦ-８ ｉｓｏｆｏｒｍｓ ａｃｔｉｖａｔｅ ｒｅｃｅｐｔｏｒ ｓｐｌｉｃｅ ｆｏｒｍｓ ｔｈａｔ ａｒｅ ｅｘｐｒｅｓｓｅｄ ｉｎ ｍｅｓｅｎｃｈｙｍａｌ ｒｅｇｉｏｎｓ ｏｆ ｍｏｕｓｅ ｄｅｖ' Ｄｅｖｅｌｏｐｍｅｎｔ Ｖｏｌ．１２１ ｎｏ．１１, 199511, ｐｐ．３６０３-３６１３
JPN6011063896; Ｍａｒｓｈ ＳＫ ｅｔ ａｌ．: 'Ｉｎｃｒｅａｓｅｄ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｆｉｂｒｏｂｌａｓｔ ｇｒｏｗｔｈ ｆａｃｔｏｒ ８ ｉｎ ｈｕｍａｎ ｂｒｅａｓｔ ｃａｎｃｅｒ．' Ｏｎｃｏｇｅｎｅ． Ｖｏｌ．１８ ｎｏ．４, 199901, ｐｐ．１０５３-１０６０
JPN6011063897; Ｃｈｅｓｉ Ｍ ｅｔ ａｌ．: 'Ｔｈｅ ｔ（４；１４） ｔｒａｎｓｌｏｃａｔｉｏｎ ｉｎ ｍｙｅｌｏｍａ ｄｙｓｒｅｇｕｌａｔｅｓ ｂｏｔｈ ＦＧＦＲ３ ａｎｄ ａ ｎｏｖｅｌ ｇｅｎｅ， ＭＭＳＥＴ， ｒｅｓｕｌｔｉｎｇ ｉｎ Ｉ' Ｂｌｏｏｄ． Ｖｏｌ．９２ ｎｏ．９, 19981101, ｐｐ．３０２５-３０３４
JPN6010060752; Ｏｈｂａｙａｓｈｉ Ｎ ｅｔ ａｌ．: 'Ｓｔｒｕｃｔｕｒｅ ａｎｄ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｔｈｅ ｍＲＮＡ ｅｎｃｏｄｉｎｇ ａ ｎｏｖｅｌ ｆｉｂｒｏｂｌａｓｔ ｇｒｏｗｔｈ ｆａｃｔｏｒ， ＦＧＦ-１８．' Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２７３巻２９号, 19980717, ｐｐ．１８１６１-１８１６４
JPN6010060753; Ｐａｓｔａｎ Ｉ ｅｔ ａｌ．: 'Ｉｍｍｕｎｏｔｏｘｉｎｓ' Ｃｅｌｌ ４７巻５号, 19861205, ｐｐ．６４１-６４８
JPN6010060755; Ｇｏｌｄｅｎｂｅｒｇ ＤＭ．: 'Ｎｅｗ ｄｅｖｅｌｏｐｍｅｎｔｓ ｉｎ ｍｏｎｏｃｌｏｎａｌ ａｎｔｉｂｏｄｉｅｓ ｆｏｒ ｃａｎｃｅｒ ｄｅｔｅｃｔｉｏｎ ａｎｄ ｔｈｅｒａｐｙ．' ＣＡ Ｃａｎｃｅｒ Ｊ Ｃｌｉｎ． ４４巻１号, 199402, ｐｐ．４３-６４
JPN6010060756; Ｍｕｒａｈａｓｈｉ Ｎ ｅｔ ａｌ．: 'Ｈｅｐａｔｉｃ ａｃｃｕｍｕｌａｔｉｏｎ ｏｆ ｇｌｕｔａｍｉｃ ａｃｉｄ ｂｒａｎｃｈｅｄ ｎｅｏｇａｌａｃｔｏｓｙｌｌｉｐｉｄ ｍｏｄｉｆｉｅｄ ｌｉｐｏｓｏｍｅｓ．' Ｂｉｏｌ Ｐｈａｒｍ Ｂｕｌｌ． ２０巻３号, 199703, ｐｐ．２５９-２６６
JPN6011063895; ＭａｃＡｒｔｈｕｒ ＣＡ ｅｔ ａｌ．: 'ＦＧＦ-８ ｉｓｏｆｏｒｍｓ ａｃｔｉｖａｔｅ ｒｅｃｅｐｔｏｒ ｓｐｌｉｃｅ ｆｏｒｍｓ ｔｈａｔ ａｒｅ ｅｘｐｒｅｓｓｅｄ ｉｎ ｍｅｓｅｎｃｈｙｍａｌ ｒｅｇｉｏｎｓ ｏｆ ｍｏｕｓｅ ｄｅｖ' Ｄｅｖｅｌｏｐｍｅｎｔ Ｖｏｌ．１２１ ｎｏ．１１, 199511, ｐｐ．３６０３-３６１３
JPN6011063896; Ｍａｒｓｈ ＳＫ ｅｔ ａｌ．: 'Ｉｎｃｒｅａｓｅｄ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｆｉｂｒｏｂｌａｓｔ ｇｒｏｗｔｈ ｆａｃｔｏｒ ８ ｉｎ ｈｕｍａｎ ｂｒｅａｓｔ ｃａｎｃｅｒ．' Ｏｎｃｏｇｅｎｅ． Ｖｏｌ．１８ ｎｏ．４, 199901, ｐｐ．１０５３-１０６０
JPN6011063897; Ｃｈｅｓｉ Ｍ ｅｔ ａｌ．: 'Ｔｈｅ ｔ（４；１４） ｔｒａｎｓｌｏｃａｔｉｏｎ ｉｎ ｍｙｅｌｏｍａ ｄｙｓｒｅｇｕｌａｔｅｓ ｂｏｔｈ ＦＧＦＲ３ ａｎｄ ａ ｎｏｖｅｌ ｇｅｎｅ， ＭＭＳＥＴ， ｒｅｓｕｌｔｉｎｇ ｉｎ Ｉ' Ｂｌｏｏｄ． Ｖｏｌ．９２ ｎｏ．９, 19981101, ｐｐ．３０２５-３０３４
JPN6010060750; Ｌａｐｐｉ ＤＡ．: 'Ｔｕｍｏｒ ｔａｒｇｅｔｉｎｇ ｔｈｒｏｕｇｈ ｆｉｂｒｏｂｌａｓｔ ｇｒｏｗｔｈ ｆａｃｔｏｒ ｒｅｃｅｐｔｏｒｓ．' Ｓｅｍｉｎ Ｃａｎｃｅｒ Ｂｉｏｌ． ６巻５号, 199510, ｐｐ．２７９-２８８
JPN6010060752; Ｏｈｂａｙａｓｈｉ Ｎ ｅｔ ａｌ．: 'Ｓｔｒｕｃｔｕｒｅ ａｎｄ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｔｈｅ ｍＲＮＡ ｅｎｃｏｄｉｎｇ ａ ｎｏｖｅｌ ｆｉｂｒｏｂｌａｓｔ ｇｒｏｗｔｈ ｆａｃｔｏｒ， ＦＧＦ-１８．' Ｊ Ｂｉｏｌ Ｃｈｅｍ． ２７３巻２９号, 19980717, ｐｐ．１８１６１-１８１６４
JPN6010060753; Ｐａｓｔａｎ Ｉ ｅｔ ａｌ．: 'Ｉｍｍｕｎｏｔｏｘｉｎｓ' Ｃｅｌｌ ４７巻５号, 19861205, ｐｐ．６４１-６４８
JPN6010060755; Ｇｏｌｄｅｎｂｅｒｇ ＤＭ．: 'Ｎｅｗ ｄｅｖｅｌｏｐｍｅｎｔｓ ｉｎ ｍｏｎｏｃｌｏｎａｌ ａｎｔｉｂｏｄｉｅｓ ｆｏｒ ｃａｎｃｅｒ ｄｅｔｅｃｔｉｏｎ ａｎｄ ｔｈｅｒａｐｙ．' ＣＡ Ｃａｎｃｅｒ Ｊ Ｃｌｉｎ． ４４巻１号, 199402, ｐｐ．４３-６４
JPN6010060756; Ｍｕｒａｈａｓｈｉ Ｎ ｅｔ ａｌ．: 'Ｈｅｐａｔｉｃ ａｃｃｕｍｕｌａｔｉｏｎ ｏｆ ｇｌｕｔａｍｉｃ ａｃｉｄ ｂｒａｎｃｈｅｄ ｎｅｏｇａｌａｃｔｏｓｙｌｌｉｐｉｄ ｍｏｄｉｆｉｅｄ ｌｉｐｏｓｏｍｅｓ．' Ｂｉｏｌ Ｐｈａｒｍ Ｂｕｌｌ． ２０巻３号, 199703, ｐｐ．２５９-２６６
JPN6011063895; ＭａｃＡｒｔｈｕｒ ＣＡ ｅｔ ａｌ．: 'ＦＧＦ-８ ｉｓｏｆｏｒｍｓ ａｃｔｉｖａｔｅ ｒｅｃｅｐｔｏｒ ｓｐｌｉｃｅ ｆｏｒｍｓ ｔｈａｔ ａｒｅ ｅｘｐｒｅｓｓｅｄ ｉｎ ｍｅｓｅｎｃｈｙｍａｌ ｒｅｇｉｏｎｓ ｏｆ ｍｏｕｓｅ ｄｅｖ' Ｄｅｖｅｌｏｐｍｅｎｔ Ｖｏｌ．１２１ ｎｏ．１１, 199511, ｐｐ．３６０３-３６１３
JPN6011063896; Ｍａｒｓｈ ＳＫ ｅｔ ａｌ．: 'Ｉｎｃｒｅａｓｅｄ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ｆｉｂｒｏｂｌａｓｔ ｇｒｏｗｔｈ ｆａｃｔｏｒ ８ ｉｎ ｈｕｍａｎ ｂｒｅａｓｔ ｃａｎｃｅｒ．' Ｏｎｃｏｇｅｎｅ． Ｖｏｌ．１８ ｎｏ．４, 199901, ｐｐ．１０５３-１０６０
JPN6011063897; Ｃｈｅｓｉ Ｍ ｅｔ ａｌ．: 'Ｔｈｅ ｔ（４；１４） ｔｒａｎｓｌｏｃａｔｉｏｎ ｉｎ ｍｙｅｌｏｍａ ｄｙｓｒｅｇｕｌａｔｅｓ ｂｏｔｈ ＦＧＦＲ３ ａｎｄ ａ ｎｏｖｅｌ ｇｅｎｅ， ＭＭＳＥＴ， ｒｅｓｕｌｔｉｎｇ ｉｎ Ｉ' Ｂｌｏｏｄ． Ｖｏｌ．９２ ｎｏ．９, 19981101, ｐｐ．３０２５-３０３４
Attorney, Agent or Firm:
Takashi Ishida (4 others)