Title:
【発明の名称】免疫抑制薬として有用な2,4-ジアミノピリミジン化合物
Document Type and Number:
Japanese Patent JP2003515602
Kind Code:
A
Abstract:
Novel compounds according to formula (I) and pharmaceutically acceptable salts, solvates, or hydrates thereof; wherein each occurrence of A is independently selected from CH or N; X is selected from the group consisting of -CH2-, -O-, -NH-, (C1-C6)alkylamino-, (C1-C6)alkylaminocarbonylamino-, (C1-C6)alkylcarbonylamino-, (C1-C6)alkylsulfonylamino-, phenylsulfonylamino-, carbonyl, -NH-C(O)-, -N(C1-C6)alkyl-C(O)-, -S(O)y- where y is 0, 1 or 2, and n in-(CH2)n- is 1, 2 or 3; and R<1>, R<2>, and R<3> are as described herein; pharmaceutical compositions that include these compounds, and methods for the treatment of autoimmune disease, inflammation, allergy, transplant rejection, and other circumstances where administration of an immunosuppressive agent is of therapeutic benefit.
Inventors:
Blumenkopf, Todd Andrew
Mueller, Eileen Elliott
Roskamp, Eric Jean
Mueller, Eileen Elliott
Roskamp, Eric Jean
Application Number:
JP2001541899A
Publication Date:
May 07, 2003
Filing Date:
November 09, 2000
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
A61K31/506; A61K31/5377; A61K45/00; A61P1/00; A61P1/02; A61P3/10; A61P5/14; A61P11/06; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P25/28; A61P29/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/04; C07D401/12; C07D401/14; C07D413/14; C07D417/14; G06F17/30; G09G5/00; (IPC1-7): C07D401/04; A61K31/506; A61K31/5377; A61K45/00; A61P1/00; A61P1/02; A61P3/10; A61P5/14; A61P11/06; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P25/28; A61P29/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/12; C07D401/14; C07D413/14; C07D417/14
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)