Title:
【発明の名称】細胞補酵素Aレベルの低下によって癌細胞を選択的に死滅させる方法
Document Type and Number:
Japanese Patent JP2003516938
Kind Code:
A
Abstract:
The invention describes a method to inhibit growth or kill cancer cells by acute depletion of free cellular Coenzyme A (CoA). This invention encompasses: any method to selectively decrease CoA in cancer cells by increasing the utilization of CoA and/or reducing its synthesis. As demonstrated herein, depletion of free CoA may be accomplished by inhibiting fatty acid synthase (FAS). This invention also includes depletion of free cellular Coenzyme A by interventions in addition to or alternative to FAS inhibition.
Inventors:
Ellen Es Pizer
Townsend, Craig A
Francis Pea, Kuha Juda
Townsend, Craig A
Francis Pea, Kuha Juda
Application Number:
JP2001536199A
Publication Date:
May 20, 2003
Filing Date:
November 13, 2000
Export Citation:
Assignee:
The Johns Hopkins University School of Medicine
International Classes:
A61K31/00; A61K31/34; A61K31/365; A61K45/00; A61K45/06; A61P35/00; A61P43/00; G01N33/15; G01N33/50; (IPC1-7): A61K45/00; A61P35/00; A61P43/00; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)