Title:
【発明の名称】ケモカイン受容体に対するヒトIgM抗体
Document Type and Number:
Japanese Patent JP2003516940
Kind Code:
A
Abstract:
Human sera from normal (i.e., non-HIV infected) individuals contain certain IgM autoantibodies reactive to chemokine and other lymphocyte-surface receptors. A subset of these IgM autoantibodies that bind to such receptors, particularly CXCR4 and CCR5 receptors, can inhibit HIV-1 from infecting cells. Progression from an asymptomatic HIV-1 infected state to AIDS is determined in part by the level of IgM autoantibodies that inhibit HIV-1 from infecting cells. The claimed invention described herein is a method of using these isolated antibodies for the inhibition of the progression of virus-mediated diseases.
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Inventors:
Peter I Robo
Application Number:
JP2001537971A
Publication Date:
May 20, 2003
Filing Date:
November 14, 2000
Export Citation:
Assignee:
Monicade corporation
International Classes:
G01N33/53; A61K39/02; A61K39/12; A61K39/395; A61P29/00; A61P31/12; A61P31/18; A61P37/06; A61P43/00; C07K16/28; C12N5/10; C12N15/02; C12P21/08; G01N33/569; G01N33/68; (IPC1-7): A61K39/395; A61K39/02; A61K39/12; A61P29/00; A61P31/12; A61P31/18; A61P37/06; A61P43/00; C12N5/10; C12N15/02; C12P21/08; G01N33/53; G01N33/569
Domestic Patent References:
| JPS62281824A | 1987-12-07 | |||
| JP2000229997A | 2000-08-22 |
Foreign References:
| US5606026A | 1997-02-25 |
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)