Title:
【発明の名称】可逆的に架橋されたハイドロゲル
Document Type and Number:
Japanese Patent JP2003517049
Kind Code:
A
Abstract:
A hydrogel composition and methods of preparing and using the same are disclosed. The hydrogel composition comprises an oxidized polysaccharide, and a cross-linker having at least two functional cross-linking groups. The cross-linker reversibly cross-links the polysaccharide and is provided in an amount to provide dangling cross-linkers. The method of preparing a hydrogel comprises the steps of providing an oxidized polysaccharide, and providing a cross-linker having at least two functional cross-linking groups. The cross-linker is mixed with the polysaccharide at a concentration of the cross-linker sufficient to form a hydrogel wherein the cross-linker reversibly cross-links the polysaccharide and has dangling cross-linkers. The hydrogels are useful, for example, for tissue engineering, cell transplantation and drug delivery applications.
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Inventors:
Lee Ken Young
Mooney David Jay
Mooney David Jay
Application Number:
JP2001541068A
Publication Date:
May 20, 2003
Filing Date:
November 27, 2000
Export Citation:
Assignee:
University of Michigan
International Classes:
A61L27/00; A61L15/16; A61L26/00; A61L27/20; C08J3/24; C08K5/00; C08L5/04; C08L101/00; (IPC1-7): C08J3/24; C08K5/00; C08L101/00
Attorney, Agent or Firm:
Kiyoaki Takita (1 person outside)