Title:
【発明の名称】血漿から安定で、長期型のトロンビンを調製するための装置および方法、並びにこれにより形成されたトロンビン
Document Type and Number:
Japanese Patent JP2003517272
Kind Code:
A
Abstract:
A sterile method for preparing stable thrombin component from a single donor's plasma in which the thrombin component is harvested simultaneously from the clotting and adhesive proteins component from the same donor plasma in less than one hour. The combined components provide an improved biological hemostatic agent and tissue sealant by virtue of its freedom from the risk of contaminating viruses or bacteria from allogenic human or bovine blood sources. The thrombin provides polymerization of the clotting and adhesive proteins in less than five seconds, and is sufficiently stable to provide that fast clotting over a six hour period. Further, the clotting times can be predictably lengthened by diluting the thrombin with saline.
Inventors:
Coero, philip, henry
God Say, James, H.
Broche, gym
Kingsley, Phil
Rock, gale
God Say, James, H.
Broche, gym
Kingsley, Phil
Rock, gale
Application Number:
JP2000563340A
Publication Date:
May 27, 2003
Filing Date:
August 05, 1999
Export Citation:
Assignee:
Thermo Genesis Corporation
International Classes:
A61K35/16; A61K38/48; A61L24/10; A61P7/04; A61P41/00; C12N9/74; G01N33/86; A61J3/00; G01N33/49; (IPC1-7): C12N9/74; A61K38/48; A61P7/04; A61P41/00
Domestic Patent References:
| JPH1052267A | 1998-02-24 | |||
| JPH03128398A | 1991-05-31 | |||
| JPH07508275A | 1995-09-14 | |||
| JPH02218618A | 1990-08-31 |
Foreign References:
| WO1996026269A1 | 1996-08-29 | |||
| WO1997004081A1 | 1997-02-06 | |||
| WO1996031245A1 | 1996-10-10 |
Attorney, Agent or Firm:
Kazuo Tashiro