Title:
【発明の名称】マトリックス亜鉛メタロプロテアーゼ阻害剤として使用可能なホスフィン性擬ペプチド
Document Type and Number:
Japanese Patent JP2003517450
Kind Code:
A
Abstract:
The invention relates to pseudo-peptides according to the formula:whereinR<1 >is a group inhibiting an amine function, or an amino acid residue or peptide with an inhibited terminal amino function,R<2 >represents the lateral chain of a natural or non-natural amino acid,R<3 >represents:1) the lateral chain of a natural amino acid except for Gly and Ala, not substituted or substituted by an aryl group,2) an aralkyl group, or3) an alkyl group comprising at least 3 carbon atoms, andR<4 >represents a lateral chain of natural or non-natural amino acid.They are useful as matrix zinc metalloprotease inhibitors, particularly in the treatment of cancer.
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Inventors:
Vincent Dives
Philip Kuniasse
Marie-Christine Rio
Atanasios Yotakis
Fabric baud
Stamania Vasilio
Paul Bassett
Philip Kuniasse
Marie-Christine Rio
Atanasios Yotakis
Fabric baud
Stamania Vasilio
Paul Bassett
Application Number:
JP2000594820A
Publication Date:
May 27, 2003
Filing Date:
January 18, 2000
Export Citation:
Assignee:
Komitsaria Talenergy Atomique
Institut Nasional de la Sante de la Cherche Medical
Center National de la Recherche Scientific
Genevieve Basset
Institut Nasional de la Sante de la Cherche Medical
Center National de la Recherche Scientific
Genevieve Basset
International Classes:
A61P9/00; A61P19/02; A61P19/04; A61P29/00; A61P35/00; A61P43/00; C07F9/30; C07F9/572; A61K31/66; C07F9/6558; (IPC1-7): C07F9/30; A61K31/66; A61P9/00; A61P19/02; A61P29/00; A61P35/00; A61P43/00; C07F9/572
Attorney, Agent or Firm:
Masatake Shiga (7 outside)