Title:
【発明の名称】インターロイキン-2の肺送達のための方法
Document Type and Number:
Japanese Patent JP2003519175
Kind Code:
A
Abstract:
Methods for administering interleukin-2 (IL-2) or variants thereof via pulmonary inhalation are provided. The methods comprise preparing a pharmaceutical composition comprising IL-2 or variants thereof for subsequent delivery as an aqueous or nonaqueous solution or suspension or a dry powder form. These compositions may further comprise a surfactant in an amount sufficient to enhance absorption of the composition following pulmonary inhalation of the composition. When used in the delivery methods of the invention, these highly absorbable compositions result in enhanced bioavailability of IL-2.
Inventors:
Chen, Baoul
Hora, Maninder
Hora, Maninder
Application Number:
JP2001549642A
Publication Date:
June 17, 2003
Filing Date:
December 27, 2000
Export Citation:
Assignee:
Chiron Corporation
International Classes:
A61K9/10; A61K9/14; A61K38/00; A61K38/20; A61K47/18; A61K47/26; A61K47/34; A61P31/00; A61K9/08; A61P35/00; A61P43/00; A61K9/16; A61K9/19; (IPC1-7): A61K38/00; A61K9/08; A61K9/10; A61K9/14; A61K47/18; A61K47/26; A61K47/34; A61P31/00; A61P35/00; A61P43/00
Domestic Patent References:
| JPH09501418A | 1997-02-10 |
Foreign References:
| WO1990000397A1 | 1990-01-25 | |||
| US5399341A | 1995-03-21 |
Attorney, Agent or Firm:
Shusaku Yamamoto (2 outside)