Title:
【発明の名称】ピリド〔2,3-d〕ピリミジン-2,7-ジアミンキナーゼ阻害剤
Document Type and Number:
Japanese Patent JP2003523357
Kind Code:
A
Abstract:
Disclosed are compounds of the formula (I) wherein: R<2>, R<7>, R<13>, R<14> and R15 are independently hydrogen, or (un)substituted lower alkyl, (un)substitued lower alkenyl, (un)substituted lower alkynyl, or (un)substituted -(CH2)nR<12>; R<5> is halogen, cyano, nitro, -R<9>, -NR<9>R<10>, or -OR<9>; R<6> is halogen, cyano, nitro, -R<9>, -NR<9>R<10>, -OR<9>, -Co2R<9>, -COR<9>, -CONR<9>R<10>, -NR<9>COR<10>, (un)substituted lower alkenyl, or (un)substituted lower alkynyl; R<8> is -CO2R<13>, -COR<13>, -CONR<13>R<14>, -CSNR<13>R<14>, -C(NR<13>)NR<14>R<15>, -SO3R<13>, -S02R<13>, -SO2NR<13>R<14>, -PO3R<13>R<14>, -POR<13>R<14>, -PO(NR<13>R<14>)2; R<9> and R<10> are independently hydrogen or (un)substituted lower alkyl; R<11> is a heteroaryl or a heterocyclic group; R<12> is a cycloalkyl, a heterocyclic, an aryl, or a heteroaryl group; and n is 0,1,2, or 3. These compounds and their pharmaceutical compositions are useful for treating cell proliferative disorders, such as cancer and restenosis. These compounds are potent inhibitors of cdks and growth factor-mediated kinases.
Inventors:
Booth, richard john
Dobrushin, Ellen Myra
Joshra, Vala Prasad Venkata Najendra
McNamara, Dennis Joseph
Too Good, Peter Lawrence
Dobrushin, Ellen Myra
Joshra, Vala Prasad Venkata Najendra
McNamara, Dennis Joseph
Too Good, Peter Lawrence
Application Number:
JP2001561006A
Publication Date:
August 05, 2003
Filing Date:
January 23, 2001
Export Citation:
Assignee:
WARNER-LAMBERT COMPANYLLC
International Classes:
A61K31/305; A61K31/519; A61P9/10; A61P17/06; A61P35/00; A61P43/00; C07D471/04; C07F9/6561; (IPC1-7): C07D471/04; A61K31/519; A61P9/10; A61P17/06; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)