Title:
【発明の名称】インテグリンアンタゴニスト
Document Type and Number:
Japanese Patent JP2003523768
Kind Code:
A
Abstract:
The present invention provides methods and compositions for inhibiting the biological activity of integrins, for inhibiting endothelial cell migration, and for inhibiting angiogenesis. In particular, the invention provides compositions comprising ADAM disintegrin domains and methods for using said compositions. In preferred embodiments the methods and compositions of the invention are used to inhibit angiogenesis and to treat diseases or conditions mediated by angiogenesis.
Inventors:
Fanslow, William Sea, The Third
Seretti, Douglas Pat
Point Indexer, Kurt Matthew
Black, Roy Alvin
Seretti, Douglas Pat
Point Indexer, Kurt Matthew
Black, Roy Alvin
Application Number:
JP2001562679A
Publication Date:
August 12, 2003
Filing Date:
February 23, 2001
Export Citation:
Assignee:
IMMUNEX CORPORATION
International Classes:
C12N15/09; A61K38/00; A61K45/00; A61K51/00; A61P1/04; A61P3/10; A61P7/02; A61P9/10; A61P17/02; A61P17/06; A61P19/02; A61P19/10; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P35/00; A61P35/04; A61P43/00; C07K14/46; C07K14/705; C07K19/00; C12N9/64; C12N15/57; C12P21/02; C12Q1/02; (IPC1-7): C12N15/09; A61K38/00; A61K45/00; A61K51/00; A61P1/04; A61P3/10; A61P7/02; A61P9/10; A61P17/02; A61P17/06; A61P19/02; A61P19/10; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P35/00; A61P35/04; A61P43/00; C07K14/46; C07K19/00; C12P21/02; C12Q1/02
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)