Title:
【発明の名称】4-置換-1H-ピロール-3-カルボン酸エステルの新規な製造方法
Document Type and Number:
Japanese Patent JP2003523997
Kind Code:
A
Abstract:
The present invention relates to a novel process for preparing pyrrole ester compounds, which are key intermediates in the preparation of farnesyl transferase inhibitors, an anti-cancer agent Horner-Emmons reaction of aldehyde compounds provides the corresponding alpha,beta-unsaturated esters, which without any separation and/or purification steps, are treated with toluenesutfonyl-methylisocyanate in the presence of base to give pyrrole esters in one-pot fashion.
Inventors:
Shin, Hyun, Eck
Oh, Sun, Tech
Chang, Ze, Hyuk
Lee, Gyu, Eun
Oh, Sun, Tech
Chang, Ze, Hyuk
Lee, Gyu, Eun
Application Number:
JP2001561735A
Publication Date:
August 12, 2003
Filing Date:
February 12, 2001
Export Citation:
Assignee:
Ergichem investment limited
International Classes:
C07D207/34; (IPC1-7): C07D207/34
Attorney, Agent or Firm:
Takashima Hajime