Title:
【発明の名称】結合体ワクチンにおいてキャリアとして使用するためのタンパク質
Document Type and Number:
Japanese Patent JP2003528157
Kind Code:
A
Abstract:
Vaccine conjugates are described comprising a capsular polysaccharide antigen conjugated to a carrier molecule, which carrier molecule is a protein associated with iron uptake by pathogenic microorganisms. The vaccine conjugate may comprise second or additional antigens also conjugated to the carrier. In a preferred embodiment, the carrier is a transferrin binding protein, in particular TbpA or TbpB. Also described are methods for conjugating the antigen/s to the carrier molecule, and to the use of transferrin binding protein in the manufacture of a carrier-antigen conjugate for vaccination. Affinity matrices comprising immobilised ligand for an iron uptake protein, and the use thereof for purifying a vaccine conjugate according to the present invention are also described.
Inventors:
Goringe, Andrew Richard
Andrew, Robinson
Hudson, Michael John
Karen Margaret, Redin
Andrew, Robinson
Hudson, Michael John
Karen Margaret, Redin
Application Number:
JP2001570298A
Publication Date:
September 24, 2003
Filing Date:
March 27, 2001
Export Citation:
Assignee:
Microbiological Research Authority
International Classes:
A61K39/09; A61K39/095; A61K39/385; A61K47/48; A61P31/04; (IPC1-7): A61K39/09; A61K39/095; A61K47/48; A61P31/04
Attorney, Agent or Firm:
Nanjo Hiromichi