Title:
【発明の名称】標的化薬物送達のための方法および組成物
Document Type and Number:
Japanese Patent JP2003530299
Kind Code:
A
Abstract:
A drug delivery molecule has a targeting moiety, coupled to a routing moiety and a bioactive molecule. The targeting moiety binds to a cell receptor without eliciting an agonistic effect and binding results in uptake of the drug delivery molecule into the cell. Contemplated drug delivery molecules may be employed for treatment and diagnosis. A method of selectively targeting an endothelial cell includes recognizing that presence or absence of somatostatin type II receptors on the endothelial cell correlates with a proximal position of the endothelial cell to an anomalous cell. Endothelial cells proximal to anomalous cells are then presented with a somatostatin type II receptor specific compound. In further methods, the presence of a somatostatin type II receptor on an endothelial cell proximal to a tissue is correlated with a disease of the tissue. In subsequent steps, somatostatin type II receptor specific compounds are administered to the endothelial cell.
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Inventors:
Graupner, Gerhard
Application Number:
JP2000603725A
Publication Date:
October 14, 2003
Filing Date:
March 08, 2000
Export Citation:
Assignee:
Graupner, Gerhard
International Classes:
A61F9/007; A61K38/00; A61K38/22; A61K45/00; A61K47/48; A61K51/00; A61P27/02; A61P35/00; A61P43/00; (IPC1-7): A61K47/48; A61F9/007; A61K38/00; A61K38/22; A61K45/00; A61K51/00; A61P27/02; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Shusaku Yamamoto