Title:
【発明の名称】6-ヒドロキシ-3-(4-[2-(ピペリジン-1-イル)エトキシ]フェノキシ)-2-(4-メトキシフェニル)ベンゾ[b]チオフェンおよびその塩の安定化製剤
Document Type and Number:
Japanese Patent JP2003535827
Kind Code:
A
Abstract:
The present invention is directed to pharmaceutical formulations containing 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene or a salt thereof; stabilized to oxidation or other forms of decomposition by incorporation of a stabilizing agent selected from methionine, acetylcysteine, cysteine or salts thereof.
Inventors:
Phadia Najar Bashore
Kelly John Heartauer
Michael Dean Minnett
Eugene Clark Rickard
Sheryl Ann Tingle
Kelly John Heartauer
Michael Dean Minnett
Eugene Clark Rickard
Sheryl Ann Tingle
Application Number:
JP2001581801A
Publication Date:
December 02, 2003
Filing Date:
April 30, 2001
Export Citation:
Assignee:
ELI LILLY AND COMPANY
International Classes:
A61K9/20; A61K9/48; A61K31/4535; A61K47/18; A61K47/20; A61P3/06; A61P9/08; A61P9/10; A61P13/08; A61P15/00; A61P19/08; A61P19/10; A61P25/00; A61P25/28; A61P35/00; A61P43/00; (IPC1-7): A61K31/4535; A61K9/20; A61K9/48; A61K47/20; A61P3/06; A61P9/08; A61P9/10; A61P13/08; A61P15/00; A61P19/08; A61P19/10; A61P25/00; A61P25/28; A61P35/00; A61P43/00
Domestic Patent References:
| JPH09183776A | 1997-07-15 |
Foreign References:
| WO1998045287A1 | 1998-10-15 |
Other References:
緒方章, 化学実験操作法上巻, JPN6010005331, 1963, pages 377, ISSN: 0002027590
HALEBLIAN，J.K.: "Characterization of Habits and Crystalline Modification of Solids and Their Pharmaceutical Applicati", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 64, no. 8, JPN6008019570, 1975, pages 1269 - 1288, ISSN: 0002027591
社団法人日本化学会編, 実験化学講座（続）２：分離と精製, JPN7008003684, 1967, pages 184 - 194, ISSN: 0002027592
社団法人日本化学会編, 第４版実験化学講座１基本操作Ｉ, JPN7008003682, 1990, pages 184 - 189, ISSN: 0002027593
社団法人日本化学会編, 実験化学ガイドブック, JPN7008003683, 1984, pages 130 - 131, ISSN: 0002027594
松本光雄編, 薬剤学マニュアル, vol. 第１版, JPN6008019571, 1989, pages 28 - 76, ISSN: 0002027595
山本英二 外: "●特集●やわらかな分離 結晶多形と分離操作", 分離技術, vol. 25, no. 5, JPN6010003451, 1995, pages 9 - 381, ISSN: 0002027596
HALEBLIAN，J.K.: "Characterization of Habits and Crystalline Modification of Solids and Their Pharmaceutical Applicati", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 64, no. 8, JPN6008019570, 1975, pages 1269 - 1288, ISSN: 0002027591
社団法人日本化学会編, 実験化学講座（続）２：分離と精製, JPN7008003684, 1967, pages 184 - 194, ISSN: 0002027592
社団法人日本化学会編, 第４版実験化学講座１基本操作Ｉ, JPN7008003682, 1990, pages 184 - 189, ISSN: 0002027593
社団法人日本化学会編, 実験化学ガイドブック, JPN7008003683, 1984, pages 130 - 131, ISSN: 0002027594
松本光雄編, 薬剤学マニュアル, vol. 第１版, JPN6008019571, 1989, pages 28 - 76, ISSN: 0002027595
山本英二 外: "●特集●やわらかな分離 結晶多形と分離操作", 分離技術, vol. 25, no. 5, JPN6010003451, 1995, pages 9 - 381, ISSN: 0002027596
Attorney, Agent or Firm:
Kaoru Aoyama (3 people outside)