Title:
皮膚浸透促進剤としての水酸化物放出剤
Document Type and Number:
Japanese Patent JP2004500360
Kind Code:
A
Abstract:
A method is provided for increasing the permeability of skin or mucosal tissue to topically or transdermally administered pharmacologically or cosmeceutically active agents. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the active agent through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Topically applied formulations and drug delivery devices employing hydroxide-releasing agents as permeation enhancers are provided as well.
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Inventors:
Luo, Eric C.
Jacobson, Eric Sea.
Sea, Song-Min
Macy, Russell
Jacobson, Eric Sea.
Sea, Song-Min
Macy, Russell
Application Number:
JP2001544911A
Publication Date:
January 08, 2004
Filing Date:
December 15, 2000
Export Citation:
Assignee:
Dermatren's, Incorporated
International Classes:
A61K9/00; A61K9/08; A61K9/107; A61K9/70; A61K31/137; A61K31/192; A61K31/196; A61K31/216; A61K31/565; A61K38/00; A61K38/095; A61K45/00; A61K47/02; A61K47/04; A61P1/00; A61P3/04; A61P3/06; A61P3/08; A61P3/10; A61P9/06; A61P9/08; A61P9/12; A61P11/06; A61P13/02; A61P17/04; A61P17/06; A61P17/10; A61P19/02; A61P21/02; A61P23/00; A61P25/00; A61P25/02; A61P25/08; A61P25/24; A61P27/06; A61P29/00; A61P31/04; A61P31/10; A61P33/10; A61K9/06; A61P35/00; A61P37/08; (IPC1-7): A61K45/00; A61K9/06; A61K9/08; A61K9/107; A61K31/137; A61K31/192; A61K31/196; A61K31/216; A61K31/565; A61K38/00; A61K38/11; A61K47/04; A61P1/00; A61P3/04; A61P3/06; A61P3/08; A61P3/10; A61P9/06; A61P9/08; A61P9/12; A61P11/06; A61P13/02; A61P17/04; A61P17/06; A61P17/10; A61P19/02; A61P21/02; A61P23/00; A61P25/00; A61P25/02; A61P25/08; A61P25/24; A61P27/06; A61P29/00; A61P31/04; A61P31/10; A61P33/10; A61P35/00; A61P37/08
Domestic Patent References:
| JPH02255612A | 1990-10-16 | |||
| JPH02243626A | 1990-09-27 | |||
| JPH035422A | 1991-01-11 | |||
| JPS63159318A | 1988-07-02 | |||
| JPS5998014A | 1984-06-06 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita