Title:
選択的シクロオキシゲナーゼ-2阻害薬の即効性製剤
Document Type and Number:
Japanese Patent JP2004500427
Kind Code:
A
Abstract:
An orally deliverable pharmaceutical composition is provided comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility, for example celecoxib, and a glycol ether, for example diethylene glycol monoethyl ether. At least a substantial part of the drug is in dissolved or solubilized form in a solvent liquid comprising the glycol ether. The composition has rapid-onset properties and is useful in treatment of cyclooxygenase-2 mediated conditions and disorders, particularly pain. For relief of pain in headache or migraine, the composition can optionally be administered together with a vasodilator.
Inventors:
Hari Haran, Madhusdan
Carlari, Togular Tea
Hassan, Fred
Forbes, James Sea
Carlari, Togular Tea
Hassan, Fred
Forbes, James Sea
Application Number:
JP2001576024A
Publication Date:
January 08, 2004
Filing Date:
April 17, 2001
Export Citation:
Assignee:
Pharmacia Corporation
International Classes:
A61K47/34; A61K9/08; A61K9/48; A61K31/00; A61K31/10; A61K31/122; A61K31/341; A61K31/351; A61K31/352; A61K31/365; A61K31/415; A61K31/42; A61K31/444; A61K31/50; A61K31/519; A61K45/06; A61K47/08; A61K47/10; A61K47/14; A61K47/38; A61K47/42; A61P9/00; A61P25/04; A61P25/06; A61P43/00; (IPC1-7): A61K47/34; A61K9/08; A61K9/48; A61K31/122; A61K31/341; A61K31/352; A61K31/415; A61K31/42; A61K31/444; A61K31/50; A61K31/519; A61K45/06; A61K47/08; A61K47/14; A61K47/38; A61K47/42; A61P9/00; A61P25/04; A61P25/06; A61P43/00
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri