Title:
選択的エストロゲン活性を有する16,17-炭素環縮合ステロイド化合物
Document Type and Number:
Japanese Patent JP2004501931
Kind Code:
A
Abstract:
The invention discloses a steroid compound having the formula (1): wherein dotted bonds represent optional double bonds; R6 is H, ═CH2, or —CH3, or —CH2—CH3; R7 is H, C1-4-alkyl, C2-5 alkenyl or C2-5-alkynyl, wherein the alkyl, alkenyl or alkynyl group may be substituted with 1 to 3 halogen atoms independently chosen from the group of fluorine or chlorine atoms; R11 is H, Cl1-4-alkyl, C2-4-alkenyl, C2-4-alkynyl or C1-4-alkylidene, wherein the alkyl, alkenyl, alkynyl or alkylidene group may be substituted with 1 to 3 halogen atoms independently chosen from the group of fluorine or chlorine atoms; E represents together with carbon atoms 16 and 17 of the steroid skeleton a four to seven-membered ring, said ring being α and in cis-configuration with respect to the steroid skeleton, optionally comprising one or two endocyclic bonds; or a prodrug thereof. Such compounds can be used in therapy and for methods for selective modification of the activity of estrogen receptors.
Inventors:
Rosen, Hiyubert Jan Josef
Application Number:
JP2002505804A
Publication Date:
January 22, 2004
Filing Date:
May 01, 2001
Export Citation:
Assignee:
Akzo Novel N B
International Classes:
A61K31/565; A61P5/30; A61P5/36; A61P15/12; A61P15/18; C07J53/00; A61K31/56; (IPC1-7): C07J53/00; A61K31/56; A61P5/30; A61P15/12; A61P15/18
Domestic Patent References:
| JPH10273499A | 1998-10-13 |
Foreign References:
| US3194821A | 1965-07-13 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuru Inoue
Akio Ichiiri
Makoto Ono
Katsuma Osaki