Title:
ルテニウム錯体および不斉水素化におけるその使用
Document Type and Number:
Japanese Patent JP2004504371
Kind Code:
A
Abstract:
A process for the preparation of an enantiomerically enriched chiral amine of formula (10), or the opposite enantiomer thereof, from an inline of formula (11)wherein (i) R1 is aryl, R2 is alkyl and R3 is aryl or aryl-CH2-, or (iii) R2 is linked with R1 and/or R3 to form one or more rings and R3 or R1 (if not in a ring) is H or a non-interfering organic group, the number of C atoms in each of R1, R2 and R3 being up to 30, comprises asymmetric hydrogenation of the imine in the presence of a base and, as catalyst, a ruthenium complex of a chiral diphosphine and a chiral diamine.
Inventors:
Kobley, Christopher James
Hensk, Julian Paul
Ramsden, James Andrew
Hensk, Julian Paul
Ramsden, James Andrew
Application Number:
JP2002514079A
Publication Date:
February 12, 2004
Filing Date:
July 20, 2001
Export Citation:
Assignee:
CHIROTECH TECHNOLOGY LIMITED
International Classes:
B01J31/24; C07B53/00; C07B61/00; C07C209/26; C07C209/52; C07C211/48; C07D209/08; C07D217/02; C07D241/42; C07F9/50; C07F15/00; C07C211/27; (IPC1-7): C07B53/00; B01J31/24; C07C209/26; C07C211/48
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji