Title:
末梢カンナビノイド受容体に特異的なアゴニスト
Document Type and Number:
Japanese Patent JP2004505006
Kind Code:
A
Abstract:
The invention provides novel pharmaceutical compositions comprising as the active ingredient 4-phenyl pinene derivatives which are specific for the peripheral cannabinoid receptors. In particular, the compounds of the invention binds efficiently to CB2 but do not bind to CB1. The compounds show no activity in behavioral tests in mice which together have been shown to be specific for tetrahydrocannabinol (THC)- type activity in the central nervous system mediated by CB1 but reduce blood pressure, block intestinal motility, and elicit anti-inflammatory and peripheral analgetic activity. The invention also relates to methods of treating, preventing, or managing hypertension, inflammation, pain, gastrointestinal diseases, autoimmune diseases, and tumors with the compounds of the invention.
Inventors:
Fride, Esther
Briar, Aviva
Hanus, Lumia
Cilibon, Susanna
Hollowitsu, Mikaru
Mekoulam, Rahuael
Garzon, Aaron
Briar, Aviva
Hanus, Lumia
Cilibon, Susanna
Hollowitsu, Mikaru
Mekoulam, Rahuael
Garzon, Aaron
Application Number:
JP2001534374A
Publication Date:
February 19, 2004
Filing Date:
October 30, 2000
Export Citation:
Assignee:
Isamu Research Development Company of the Hebrew University
International Classes:
A61K31/085; A61K31/09; A61K31/192; A61K31/216; A61K31/222; A61P1/00; A61P9/12; A61P25/02; A61P29/00; A61P35/00; A61P37/06; C07C43/23; C07C62/32; C07C69/025; C07C69/24; C07C69/734; A61K31/695; (IPC1-7): A61K31/085; A61K31/09; A61K31/192; A61K31/222; A61K31/695; A61P1/00; A61P9/12; A61P25/02; A61P29/00; A61P35/00; A61P37/06; C07C43/23; C07C62/32; C07C69/025; C07C69/24; C07C69/734
Attorney, Agent or Firm:
Heikichi Odashima