Title:
スクロース-6-エステル化合物の改良された合成方法
Document Type and Number:
Japanese Patent JP2004505092
Kind Code:
A
Abstract:
There is described a process for the synthesis of a sucrose-6-ester comprising: (a) reacting a mixture comprising sucrose and a polar aprotic solvent with an organotin-based acylation promoter, while adding a solvent capable of removing water by co-distillation, and removing water by co-distillation, to afford a first reaction mixture which is substantially free from water, followed by (b) adding a carboxylic anhydride to said first reaction mixture to afford a second reaction mixture, and maintaining said second reaction mixture at a temperature and for a period of time sufficient to produce a sucrose-6-ester, characterised in that step (a) is performed at a temperature of from 85 to 125° C. and at a pressure of from 20 to 80 kPa. In the most preferred embodiment, the polar aprotic solvent is DMF, the solvent capable of removing water by co-distillation is cyclohexane, the organotion-based acylation promoter is a 1,3-diacyloxy-1,1,3,3-tetrabutyldistannoxane, and step (a) is performed at approximately 97° C., and approximately 50 kpa, until the weight ratio of tin to water in the first reaction mixture is greater than about 26, when the tin content is measured by X-Ray Fluoresence Analyzer, and the water content is measured by the Karl-Fischer method.
Inventors:
Clark, Jason, Dee
Lemei, Richard, Earl, Junior
Lemei, Richard, Earl, Junior
Application Number:
JP2002515909A
Publication Date:
February 19, 2004
Filing Date:
July 19, 2001
Export Citation:
Assignee:
Tate and Lyle Public Limited Company
International Classes:
B01J31/12; C07B61/00; C07H13/02; C07H13/04; C07H13/06; (IPC1-7): C07H13/06; B01J31/12
Domestic Patent References:
| JPH04270297A | 1992-09-25 | |||
| JPH09309894A | 1997-12-02 | |||
| JPH04225993A | ||||
| JPS61100529A | 1986-05-19 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Masahiro Asamura
Hajime Asamura
Yukihiro Ikeda
Masahiro Asamura