Title:
遺伝性乳白色ゾウゲ質における突然変異遺伝子dsppの検出方法
Document Type and Number:
Japanese Patent JP2004508067
Kind Code:
A
Abstract:
The present invention involves a method of detecting mutant DSPP gene of hereditary opalescent dentin. The invention locates the mutation locus resulting in hereditary opalescent dentin in the third exon of dspp, and describes the application of said method in the diagnosis and therapy of hereditary opalescent dentin cases. Thereby the invention sets the foundation for further studies on the mineralizing process of teeth, nosogenetic mechanism of hereditary opalescent dentin, as well as their utilities in clinic and antenatal diagnosis. The invention also provides a kit and its use in the diagnosis and therapy of patients with hereditary opalescent dentin.
Inventors:
Settling
Zhao Army
Zhanghai sea
Zhao Army
Zhanghai sea
Application Number:
JP2002527304A
Publication Date:
March 18, 2004
Filing Date:
September 15, 2000
Export Citation:
Assignee:
Beijing Nosai Foundation Research Center Co., Ltd.
International Classes:
G01N33/53; A61K48/00; A61P1/02; A61P43/00; C12N15/09; C12Q1/68; G01N27/447; G01N33/566; (IPC1-7): C12N15/09; A61K48/00; A61P1/02; A61P43/00; C12Q1/68; G01N27/447; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda