HIV-1逆転写酵素二量体化を検出するツーハイブリッド試験 - THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Title:

HIV-1逆転写酵素二量体化を検出するツーハイブリッド試験

Document Type and Number:

Japanese Patent JP2004509614

Kind Code:

A

Abstract:

This invention provides methods of determining whether a compound inhibits HIV-1 reverse transcriptase. This invention provides methods of determining whether a compound inhibits formation of a complex between a p66 and p51 subunit polypeptides of HIV-1 reverse transcriptase. This invention provides a method of determining whether a compound enhances formation of a complex between a p66 and p51 subunit polypeptides of HIV-1 reverse transcriptase. This invention provides methods of determining whether a compound inhibits formation of a complex between two p66 subunit polypeptides of HIV-1 reverse transcriptase. This invention provides methods of determining whether a compound enhances formation of a complex between two p66 subunit polypeptides of HIV-1 reverse transcriptase.

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Inventors:

Goff, Stephen Pee
Tachejan, Guilda

Application Number:

JP2002502185A

Publication Date:

April 02, 2004

Filing Date:

June 06, 2001

Export Citation:

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Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

International Classes:

C12Q1/02; A61K9/127; A61K45/00; A61P31/18; A61P43/00; C12N9/12; C12P21/04; C12Q1/68; (IPC1-7): C12Q1/02; A61K9/127; A61K45/00; A61P31/18; A61P43/00

Attorney, Agent or Firm:

Takehiko Suzue
Sadao Muramatsu
Ryo Hashimoto
Toshio Shirane

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