Title:
酵素-分解性プロドラッグ化合物
Document Type and Number:
Japanese Patent JP2004510703
Kind Code:
A
Abstract:
The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavage sequences within the conjugate and methods of treating patients with prodrugs of the invention.
Inventors:
Kneader, Matthew H.
DuBois, Vincent
Gangwa, sanjeev
Roble, Thomas Jay.
Pickford, Leslie Bee.
Andre, Troweto
Yarlanton, Jeffrey Tea.
DuBois, Vincent
Gangwa, sanjeev
Roble, Thomas Jay.
Pickford, Leslie Bee.
Andre, Troweto
Yarlanton, Jeffrey Tea.
Application Number:
JP2002510122A
Publication Date:
April 08, 2004
Filing Date:
June 11, 2001
Export Citation:
Assignee:
Medarex, Incorporated
International Classes:
A61K31/704; A61K47/48; A61P29/00; A61P31/00; A61P35/00; A61P43/00; (IPC1-7): A61K47/48; A61K31/704; A61P29/00; A61P31/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2003518000A | 2003-06-03 |
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji